Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AXL | P30530 | 2/20 | 0.51 |
| ▸ | MERTK | Q12866 | 2/20 | 0.51 |
| ▸ | TYRO3 | Q06418 | 1/20 | 0.51 |
| ▸ | FLT3 | P36888 | 1/20 | 0.49 |
| ▸ | TLR7 | Q9NYK1 | 7/20 | 0.47 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.47 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.47 |
| ▸ | PDE8A | O60658 | 1/20 | 0.44 |
| ▸ | NUDT1 | P36639 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3957420 | 0.89 | AXL (0.51) | AXLMERTKTYRO3FLT3TLR7 | |
| SCHEMBL7206653 | 0.83 | TLR7 (0.51) | TLR7ADORA2AADORA1NUDT1 | |
| SCHEMBL509407 | 0.83 | TLR7 (0.64) | TLR7ADORA2ANUDT1 | |
| SCHEMBL16481581 | 0.82 | TLR7 (0.52) | TLR7ADORA2APDE8ANUDT1 | |
| SCHEMBL2058751 | 0.80 | TLR7 (0.50) | TLR7ADORA2ANUDT1 | |
| SCHEMBL3922033 | 0.80 | YTHDC1 (0.53) | TLR7ADORA2AADORA1NUDT1 | |
| SCHEMBL17154082 | 0.80 | TLR7 (0.52) | TLR7PDE8ANUDT1 | |
| SCHEMBL9738975 | 0.80 | ADORA2A (0.65) | AXLMERTKTYRO3FLT3ADORA2A | |
| SCHEMBL9738479 | 0.79 | AXL (0.53) | AXLMERTKTYRO3FLT3ADORA2A | |
| SCHEMBL12305232 | 0.79 | TLR7 (0.46) | TLR7NUDT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009034386-A1 | DERIVATIVES OF ADENINE AND 8-AZA-ADENINE AND USES THEREOF-796 | ASTRAZENECA AB (SE) | 2009-03-19 | — | — | WO | claimed |
| WO-2009034386-A1 | DERIVATIVES OF ADENINE AND 8-AZA-ADENINE AND USES THEREOF-796 | ASTRAZENECA AB (SE) | 2009-03-19 | — | — | WO | disclosed |