Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | VCP | P55072 | 13/20 | 0.58 |
| ▸ | ACACB | O00763 | 3/20 | 0.46 |
| ▸ | ACACA | Q13085 | 3/20 | 0.46 |
| ▸ | JAK2 | O60674 | 1/20 | 0.44 |
| ▸ | JAK3 | P52333 | 1/20 | 0.44 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.43 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.43 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.43 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.43 |
| ▸ | USP30 | Q70CQ3 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2581731 | 0.83 | VCP (0.54) | VCPACACBACACA | |
| SCHEMBL27560856 | 0.76 | MAPK14 (0.42) | VCPMAPK13MAPK12MAPK11MAPK14 | |
| SCHEMBL3645812 | 0.75 | CYP11B2 (0.57) | VCP | |
| SCHEMBL21621308 | 0.75 | MAPK14 (0.62) | VCPMAPK13MAPK12MAPK11MAPK14 | |
| SCHEMBL3957879 | 0.74 | HDAC8 (0.43) | USP30 | |
| SCHEMBL3956297 | 0.74 | AAK1 (0.48) | — | |
| SCHEMBL34464863 | 0.74 | AAK1 (0.51) | — | |
| SCHEMBL2581961 | 0.73 | VCP (0.59) | VCPJAK2JAK3MAPK13MAPK12 | |
| SCHEMBL12001468 | 0.72 | ACACB (0.69) | VCPACACBJAK2JAK3 | |
| SCHEMBL3652082 | 0.72 | JAK2 (0.49) | VCPJAK2JAK3USP30 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009034390-A1 | HETEROCYCLIC DERIVATIVES AND THEIR USE IN TREATING HEPATITIS C | ARROW THERAPEUTICS LIMITED (GB) | 2009-03-19 | — | — | WO | disclosed |