Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.66 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.58 |
| ▸ | TSHR | P16473 | 4/20 | 0.58 |
| ▸ | TP53 | P04637 | 3/20 | 0.58 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.58 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.58 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.58 |
| ▸ | MEN1 | O00255 | 3/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.56 |
| ▸ | MAPT | P10636 | 2/20 | 0.56 |
| ▸ | HPGD | P15428 | 2/20 | 0.56 |
| ▸ | PKM | P14618 | 2/20 | 0.56 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.56 |
| ▸ | PPARG | P37231 | 1/20 | 0.56 |
| ▸ | LMNA | P02545 | 1/20 | 0.56 |
| ▸ | GAA | P10253 | 1/20 | 0.56 |
| ▸ | GLA | P06280 | 1/20 | 0.50 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.38 |
| ▸ | SRC | P12931 | 1/20 | 0.38 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27904123 | 1.00 | TDP1 (0.66) | TDP1ALDH1A1TSHRTP53HIF1A | |
| SCHEMBL134200 | 1.00 | TDP1 (0.66) | TDP1ALDH1A1TSHRTP53HIF1A | |
| SCHEMBL50264 | 0.85 | TDP1 (0.79) | TDP1ALDH1A1TSHRTP53HIF1A | |
| SCHEMBL20677146 | 0.85 | TDP1 (0.79) | TDP1ALDH1A1TSHRTP53HIF1A | |
| SCHEMBL21094081 | 0.85 | TDP1 (0.79) | TDP1ALDH1A1TSHRTP53HIF1A | |
| SCHEMBL20590552 | 0.84 | TDP1 (0.47) | TDP1ALDH1A1TSHRTP53HIF1A | |
| SCHEMBL5707438 | 0.82 | ALDH1A1 (0.51) | TDP1ALDH1A1TSHRTP53HIF1A | |
| SCHEMBL9055789 | 0.82 | TDP1 (0.46) | TDP1ALDH1A1TSHRTP53HIF1A | |
| Water SCHEMBL11032953 | 0.82 | TDP1 (0.68) | TDP1ALDH1A1TSHRTP53HIF1A | |
| Water SCHEMBL6248999 | 0.82 | TDP1 (0.96) | TDP1ALDH1A1TSHRTP53HIF1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2035435-A1 | NOVEL LAPACHONE COMPOUNDS AND METHODS OF USE THEREOF | ARQULE, INC. (US) | 2009-03-18 | — | — | EP | disclosed |
| WO-2007139569-A1 | NOVEL LAPACHONE COMPOUNDS AND METHODS OF USE THEREOF | ARQULE, INC. (US) | 2007-12-06 | — | — | WO | disclosed |