Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.43 |
| ▸ | AGTR2 | P50052 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | SLC27A1 | Q6PCB7 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | MGLL | Q99685 | 1/20 | 0.38 |
| ▸ | CKS1B | P61024 | 2/20 | 0.37 |
| ▸ | SKP1 | P63208 | 2/20 | 0.37 |
| ▸ | SKP2 | Q13309 | 2/20 | 0.37 |
| ▸ | ME2 | P23368 | 4/20 | 0.37 |
| ▸ | ME1 | P48163 | 4/20 | 0.37 |
| ▸ | ME3 | Q16798 | 4/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | AURKA | O14965 | 1/20 | 0.36 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5132617 | 0.88 | CKS1B (0.47) | MEN1KMT2ACKS1BSKP1SKP2 | |
| SCHEMBL5128354 | 0.86 | MAPT (0.43) | MAPTAGTR1AGTR2SLC27A1ALDH1A1 | |
| Hydrochloric Acid SCHEMBL5122602 | 0.86 | MAPT (0.42) | MAPTAGTR1AGTR2SLC27A1ALDH1A1 | |
| SCHEMBL3965077 | 0.82 | SYK (0.40) | MAPTAGTR1AGTR2MEN1KMT2A | |
| SCHEMBL3963579 | 0.80 | AGTR1 (0.44) | MAPTAGTR1AGTR2MEN1KMT2A | |
| SCHEMBL3955412 | 0.78 | MAPT (0.49) | MAPTAGTR1AGTR2ALDH1A1KDM4E | |
| SCHEMBL3961800 | 0.77 | AGTR1 (0.43) | MAPTAGTR1AGTR2MEN1KMT2A | |
| SCHEMBL3961045 | 0.76 | GFER (0.49) | MAPTAGTR1AGTR2KMT2ANPC1 | |
| SCHEMBL3953186 | 0.76 | MAPT (0.59) | MAPTAGTR1AGTR2ALDH1A1KDM4E | |
| SCHEMBL3957534 | 0.75 | MAPT (0.54) | MAPTAGTR1AGTR2KMT2AKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2079737-A1 | PYRIDOPYRIMIDINONE COMPOUNDS USEFUL IN TREATING SODIUM CHANNEL-MEDIATED DISEASES OR CONDITIONS | XENON PHARMACEUTICALS INC. (CA) | 2009-07-22 | — | — | EP | claimed |
| WO-2008097991-A1 | PYRIDOPYRIMIDINONE COMPOUNDS USEFUL IN TREATING SODIUM CHANNEL-MEDIATED DISEASES OR CONDITIONS | XENON PHARMACEUTICALS INC. (CA) | 2008-08-14 | — | — | WO | claimed |
| EP-2079737-A1 | PYRIDOPYRIMIDINONE COMPOUNDS USEFUL IN TREATING SODIUM CHANNEL-MEDIATED DISEASES OR CONDITIONS | XENON PHARMACEUTICALS INC. (CA) | 2009-07-22 | — | — | EP | disclosed |
| WO-2008097991-A1 | PYRIDOPYRIMIDINONE COMPOUNDS USEFUL IN TREATING SODIUM CHANNEL-MEDIATED DISEASES OR CONDITIONS | XENON PHARMACEUTICALS INC. (CA) | 2008-08-14 | — | — | WO | disclosed |