Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR6 | P50406 | 1/20 | 1.00 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.49 |
| ▸ | MEN1 | O00255 | 3/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.49 |
| ▸ | LMNA | P02545 | 3/20 | 0.45 |
| ▸ | RECQL | P46063 | 1/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | ALPL | P05186 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | HPGD | P15428 | 2/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | THRB | P10828 | 2/20 | 0.42 |
| ▸ | TP53 | P04637 | 2/20 | 0.42 |
| ▸ | CASP1 | P29466 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | BRD4 | O60885 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3963801 | 0.90 | HTR6 (0.82) | HTR6SMN1; SMN2MEN1KMT2ALMNA | |
| SCHEMBL3960019 | 0.90 | HTR6 (0.81) | HTR6SMN1; SMN2MEN1KMT2ALMNA | |
| SCHEMBL13361991 | 0.88 | HTR6 (0.79) | HTR6SMN1; SMN2MEN1KMT2ALMNA | |
| SCHEMBL3956245 | 0.88 | HTR6 (0.78) | HTR6SMN1; SMN2MEN1KMT2AL3MBTL1 | |
| SCHEMBL3324077 | 0.86 | HTR6 (0.76) | HTR6SMN1; SMN2MEN1KMT2ALMNA | |
| SCHEMBL3324083 | 0.86 | HTR6 (0.76) | HTR6SMN1; SMN2MEN1KMT2ALMNA | |
| Hydrochloric Acid SCHEMBL1064611 | 0.86 | HTR6 (0.75) | HTR6SMN1; SMN2MEN1KMT2ALMNA | |
| Hydrochloric Acid SCHEMBL1064070 | 0.86 | HTR6 (0.75) | HTR6SMN1; SMN2MEN1KMT2ALMNA | |
| Hydrochloric Acid SCHEMBL1064074 | 0.86 | HTR6 (0.75) | HTR6SMN1; SMN2MEN1KMT2ALMNA | |
| Hydrochloric Acid SCHEMBL1064605 | 0.86 | HTR6 (0.75) | HTR6SMN1; SMN2MEN1KMT2ALMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7582767-B2 | Substituted sulphonamide compound and uses thereof | BIOVITRUM AB (PUBL.) (SE) | 2009-09-01 | — | — | US | disclosed |
| EP-1896460-B1 | BENZOFURANYL DERIVATIVES AS 5-HT6-RECEPTOR INHIBITORS | BIOVITRUM AB PUBL (SE) | 2009-07-22 | — | — | EP | disclosed |
| EP-1896460-A1 | BENZOFURANYL DERIVATIVES AS 5-HT6-RECEPTOR INHIBITORS | Biovitrum AB (publ) (SE) | 2008-03-12 | — | — | EP | disclosed |
| US-20060293361-A1 | N-[7-(4-piperidinyl)oxy-1-benzofuran-5-yl]-5-hydroxymethyl-2-methoxybenzenesulfonamide; the prophylaxis and treatment of medical conditions relating to obesity, type II diabetes, CNS disorders, to achieve reduction of body weight and/or body weight gain | PROXIMAGEN NEUROSCIENCE PLC (GB) | 2006-12-28 | — | — | US | disclosed |
| WO-2006134150-A1 | BENZOFURANYL DERIVATIVES AS 5-HT6-RECEPTOR INHIBITORS | BIOVITRUM AB (PUBL) (SE) | 2006-12-21 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060293361-A1 | N-[7-(4-piperidinyl)oxy-1-benzofuran-5-yl]-5-hydroxymethyl-2-methoxybenzenesulfonamide; the prophylaxis and treatment of medical conditions relating to obesity, type II diabetes, CNS disorders, to achieve reduction of body weight and/or body weight gain | GPR119, CNR2, SULT1E1 | HTR6 598/4885SMN1; SMN2 256/4885MEN1 1861/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.