Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPY5R | Q15761 | 1/20 | 0.34 |
| ▸ | CTSK | P43235 | 3/20 | 0.33 |
| ▸ | CTSL | P07711 | 2/20 | 0.33 |
| ▸ | CTSB | P07858 | 2/20 | 0.33 |
| ▸ | CTSH | P09668 | 1/20 | 0.33 |
| ▸ | MGLL | Q99685 | 1/20 | 0.31 |
| ▸ | PSEN1 | P49768 | 2/20 | 0.30 |
| ▸ | PSEN2 | P49810 | 2/20 | 0.30 |
| ▸ | APH1B | Q8WW43 | 2/20 | 0.30 |
| ▸ | NCSTN | Q92542 | 2/20 | 0.30 |
| ▸ | APH1A | Q96BI3 | 2/20 | 0.30 |
| ▸ | PSENEN | Q9NZ42 | 2/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4974850 | 1.00 | NPY5R (0.34) | NPY5RCTSKCTSLCTSBCTSH | |
| SCHEMBL4071170 | 1.00 | NPY5R (0.34) | NPY5RCTSKCTSLCTSBCTSH | |
| SCHEMBL1567518 | 0.80 | NPY5R (0.31) | NPY5RCTSKCTSLCTSBMGLL | |
| SCHEMBL1568379 | 0.77 | PSEN1 (0.31) | NPY5RMGLLPSEN1PSEN2APH1B | |
| SCHEMBL4975225 | 0.77 | PSEN1 (0.31) | NPY5RMGLLPSEN1PSEN2APH1B | |
| SCHEMBL3338663 | 0.76 | PSEN1 (0.31) | NPY5RPSEN1PSEN2APH1BNCSTN | |
| SCHEMBL4078795 | 0.76 | PSEN1 (0.31) | NPY5RPSEN1PSEN2APH1BNCSTN | |
| SCHEMBL499123 | 0.76 | MGLL (0.31) | CTSKCTSLCTSBCTSHMGLL | |
| SCHEMBL4752804 | 0.75 | MGLL (0.33) | NPY5RMGLL | |
| SCHEMBL3970801 | 0.75 | MGLL (0.33) | NPY5RMGLL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2074108-A1 | RENIN INHIBITORS | Vitae Pharmaceuticals, Inc. (US) | 2009-07-01 | — | — | EP | disclosed |
| WO-2009038715-A1 | PROCESS FOR THE PREPARATION OF RENIN INHIBITORS | VITAE PHARMACEUTICALS, INC. (US) | 2009-03-26 | — | — | WO | disclosed |
| WO-2008036247-A1 | RENIN INHIBITORS | VITAE PHARMACEUTICALS, INC. (US) | 2008-03-27 | — | — | WO | disclosed |