Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRL1 | P41146 | 18/20 | 0.51 |
| ▸ | OPRM1 | P35372 | 15/20 | 0.51 |
| ▸ | PDE5A | O76074 | 1/20 | 0.44 |
| ▸ | PDE1A | P54750 | 1/20 | 0.44 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.44 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.44 |
| ▸ | PDE7A | Q13946 | 1/20 | 0.44 |
| ▸ | PDE1C | Q14123 | 1/20 | 0.44 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.44 |
| ▸ | CNR2 | P34972 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3959866 | 0.87 | OPRL1 (0.48) | OPRL1OPRM1PDE5APDE1APDE1B | |
| SCHEMBL3958965 | 0.74 | OPRL1 (0.45) | OPRL1OPRM1 | |
| SCHEMBL242117 | 0.74 | OPRL1 (0.45) | OPRL1OPRM1 | |
| SCHEMBL3959725 | 0.71 | OPRL1 (0.44) | OPRL1OPRM1PDE4D | |
| SCHEMBL3963836 | 0.71 | MGAM (0.48) | OPRL1OPRM1PDE4DPDE3A | |
| SCHEMBL240013 | 0.70 | OPRL1 (0.62) | OPRL1OPRM1 | |
| SCHEMBL242124 | 0.70 | OPRL1 (0.47) | OPRL1OPRM1PDE7A | |
| SCHEMBL12235918 | 0.69 | OPRL1 (0.50) | OPRL1OPRM1 | |
| SCHEMBL22800047 | 0.68 | OPRM1 (0.67) | OPRL1OPRM1 | |
| SCHEMBL3647216 | 0.68 | TSHR (0.68) | PDE5APDE1APDE1BPDE4DPDE7A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009034062-A1 | COMPOUNDS WHICH INHIBIT THE GLYCINE TRANSPORTER AND USES THEREOF IN MEDICINE | GLAXO GROUP LIMITED (GB) | 2009-03-19 | — | — | WO | disclosed |
| WO-2009034062-A1 | COMPOUNDS WHICH INHIBIT THE GLYCINE TRANSPORTER AND USES THEREOF IN MEDICINE | GLAXO GROUP LIMITED (GB) | 2009-03-19 | — | — | WO | disclosed |