Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN4A | P35499 | 4/20 | 0.45 |
| ▸ | MAPT | P10636 | 4/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.38 |
| ▸ | NPC1 | O15118 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | RAB9A | P51151 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | AR | P10275 | 1/20 | 0.35 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.34 |
| ▸ | HCRTR1 | O43613 | 2/20 | 0.33 |
| ▸ | HCRTR2 | O43614 | 2/20 | 0.33 |
| ▸ | RECQL | P46063 | 1/20 | 0.33 |
| ▸ | CA1 | P00915 | 1/20 | 0.33 |
| ▸ | CA2 | P00918 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL105209 | 0.84 | KMT2A (0.50) | MAPTALDH1A1KMT2ANPC1LMNA | |
| SCHEMBL5346265 | 0.79 | KMT2A (0.56) | SCN4AMAPTALDH1A1KMT2ANPC1 | |
| Hydrochloric Acid SCHEMBL15326972 | 0.78 | SCN4A (0.47) | SCN4AMAPTALDH1A1KMT2ANPC1 | |
| Hydrochloric Acid SCHEMBL15327024 | 0.78 | SCN4A (0.47) | SCN4AMAPTALDH1A1KMT2ANPC1 | |
| SCHEMBL102272 | 0.77 | PTGS2 (0.51) | CA1CA2 | |
| SCHEMBL102255 | 0.75 | MET (0.36) | SCN4AALDH1A1NPC1RAB9A | |
| SCHEMBL26112584 | 0.75 | SCN4A (0.51) | SCN4AMAPTALDH1A1KMT2ANPC1 | |
| SCHEMBL9977807 | 0.74 | SCN4A (0.48) | SCN4AMAPTALDH1A1KMT2ANPC1 | |
| SCHEMBL394278 | 0.74 | NPC1 (0.44) | ALDH1A1KMT2ANPC1LMNARAB9A | |
| Hydrochloric Acid SCHEMBL15327072 | 0.73 | SCN4A (0.47) | SCN4AMAPTALDH1A1KMT2ANPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8101637-B2 | Alkynyl derivatives as modulators of metatropic glutamate receptors | ADDEX PHARMA SA (CH) | 2012-01-24 | — | — | US | disclosed |