Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR84 | Q9NQS5 | 2/20 | 0.49 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | NR4A2 | P43354 | 2/20 | 0.44 |
| ▸ | CTNNB1 | P35222 | 1/20 | 0.43 |
| ▸ | WNT3A | P56704 | 1/20 | 0.43 |
| ▸ | BRPF1 | P55201 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | PBRM1 | Q86U86 | 1/20 | 0.41 |
| ▸ | ATM | Q13315 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | THRB | P10828 | 1/20 | 0.40 |
| ▸ | DNMT1 | P26358 | 1/20 | 0.40 |
| ▸ | RECQL | P46063 | 1/20 | 0.40 |
| ▸ | CASP6 | P55212 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3721316 | 0.87 | GPR84 (0.49) | GPR84NPC1NR4A2CTNNB1WNT3A | |
| SCHEMBL3995494 | 0.86 | GPR84 (0.51) | GPR84NPC1NR4A2CTNNB1WNT3A | |
| SCHEMBL23538240 | 0.85 | GPR84 (0.47) | GPR84NPC1NR4A2CTNNB1WNT3A | |
| SCHEMBL15356576 | 0.83 | PBRM1 (0.56) | GPR84NPC1NR4A2CTNNB1WNT3A | |
| SCHEMBL18837110 | 0.83 | NR4A2 (0.51) | GPR84NPC1NR4A2CTNNB1WNT3A | |
| SCHEMBL11795053 | 0.81 | GPR84 (0.50) | GPR84NPC1NR4A2CTNNB1WNT3A | |
| SCHEMBL1558360 | 0.80 | HTR2A (0.49) | GPR84NR4A2ALDH1A1ATMGAA | |
| SCHEMBL16791407 | 0.80 | GPR84 (0.49) | GPR84NPC1NR4A2CTNNB1WNT3A | |
| SCHEMBL2309708 | 0.79 | HSD17B10 (0.55) | GPR84NPC1NR4A2CTNNB1WNT3A | |
| SCHEMBL9937305 | 0.79 | NR4A2 (0.70) | GPR84NPC1NR4A2CTNNB1WNT3A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7544685-B2 | 2,3-dihydroindole compounds | H. LUNDBECK A/S (DK) | 2009-06-09 | — | — | US | disclosed |
| CN-101243075-A | Novel 2,3-dihydroindole compounds | LUNDBECK & CO AS H (DK) | 2008-08-13 | — | — | CN | disclosed |
| EP-1928860-A1 | NOVEL 2,3-DIHYDROINDOLE COMPOUNDS | H.Lundbeck A/S (DK) | 2008-06-11 | — | — | EP | disclosed |
| WO-2007019867-A1 | NOVEL 2,3-DIHYDROINDOLE COMPOUNDS | H. LUNDBECK A/S (DK) | 2007-02-22 | — | — | WO | disclosed |
| US-20070043058-A1 | Novel 2,3-dihydroindole compounds | H. LUNDBECK A/S (DK) | 2007-02-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070043058-A1 | Novel 2,3-dihydroindole compounds | HTR2C, HTR2A, HTR5A | GPR84 95/4885NPC1 1063/4885NR4A2 256/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.