Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GLA | P06280 | 1/20 | 0.37 |
| ▸ | PLK1 | P53350 | 2/20 | 0.37 |
| ▸ | BRD4 | O60885 | 2/20 | 0.36 |
| ▸ | BRPF1 | P55201 | 2/20 | 0.36 |
| ▸ | CREBBP | Q92793 | 2/20 | 0.36 |
| ▸ | EP300 | Q09472 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.32 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.31 |
| ▸ | ALPL | P05186 | 1/20 | 0.31 |
| ▸ | USP2 | O75604 | 1/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
| ▸ | HTT | P42858 | 2/20 | 0.31 |
| ▸ | RAB9A | P51151 | 1/20 | 0.31 |
| ▸ | YTHDC1 | Q96MU7 | 1/20 | 0.30 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6633569 | 0.89 | GLA (0.34) | GLAALDH1A1SMN1; SMN2MAPT | |
| SCHEMBL3827995 | 0.87 | GLA (0.37) | GLAALDH1A1SMN1; SMN2MAPTTSHR | |
| SCHEMBL7851736 | 0.83 | PTPN11 (0.31) | BRD4BRPF1CREBBPEP300PTPN11 | |
| SCHEMBL1349 | 0.81 | GLA (0.40) | GLAALDH1A1SMN1; SMN2MAPTHCAR2 | |
| SCHEMBL6442196 | 0.77 | CHRM4 (0.39) | RAB9A | |
| SCHEMBL4744537 | 0.76 | SMN1; SMN2 (0.41) | PLK1BRD4BRPF1CREBBPEP300 | |
| SCHEMBL27848537 | 0.74 | BRD4 (0.37) | BRD4BRPF1CREBBPEP300ALDH1A1 | |
| SCHEMBL6447518 | 0.73 | RAB9A (0.51) | ALDH1A1SMN1; SMN2POLBRAB9AKDM4E | |
| SCHEMBL8187632 | 0.71 | TLR8 (0.41) | ALDH1A1MAPTTSHRRAB9AKDM4E | |
| SCHEMBL27614783 | 0.68 | SMN1; SMN2 (0.35) | GLAALDH1A1SMN1; SMN2MAPTHCAR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 17 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2001022918-A2 | METHOD OF PREPARATION OF SILDENAFIL | INST FARMACEUTYCZNY (PL) | 2001-04-05 | — | — | WO | claimed |
| WO-2009124119-A2 | PHOSPHODIESTERASE INHIBITORS AND USES THEREOF | The Trustes of Columbia University in the City of New York (US) | 2009-10-08 | — | — | WO | disclosed |
| WO-2009071707-A1 | NOVEL COMPOUNDS USEFUL FOR THE TREATMENT OF DEGENERATIVE & INFLAMMATORY DISEASES | GALAPAGOS NV (BE) | 2009-06-11 | — | — | WO | disclosed |
| WO-2009071706-A1 | PYRAZOLEPYRIMIDINE COMPOUNDS USEFUL FOR THE TREATMENT OF DEGENERATIVE & INFLAMMATORY DISEASES | GALAPAGOS NV (BE) | 2009-06-11 | — | — | WO | disclosed |
| EP-2024369-A2 | NOVEL PROCESS FOR THE PREPARATION OF SILDENAFIL CITRATE | Matrix Laboratories Ltd (IN) | 2009-02-18 | — | — | EP | disclosed |
| WO-2008071650-A2 | NOVEL COMPOUNDS USEFUL FOR THE TREATMENT OF DEGENERATIVE & INFLAMMATORY DISEASES | GALAPAGOS N.V. (BE) | 2008-06-19 | — | — | WO | disclosed |
| WO-2007141805-A2 | NOVEL PROCESS FOR THE PREPARATION OF SILDENAFIL CITRATE | MATRIX LABORATORIES LIMITED (IN) | 2007-12-13 | — | — | WO | disclosed |
| EP-1444234-A2 | DEUTERATED PYRAZOLOPYRIMIDINONES AND DRUGS CONTAINING SAID COMPOUNDS | Turicum Drug Development AG (CH) | 2004-08-11 | — | — | EP | disclosed |
| WO-2003053974-A1 | NOVEL COMPOUNDS AND THEIR USE IN MEDICINE, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | DR. REDDY'S LABORATORIES LTD. (IN) | 2003-07-03 | — | — | WO | disclosed |
| WO-2003039439-A2 | DEUTERATED PYRAZOLOPYRIMIDINONES AND DRUGS CONTAINING SAID COMPOUNDS | TURICUM DRUG DEVELOPMENT AG (CH) | 2003-05-15 | — | — | WO | disclosed |
| WO-2002016364-A1 | POLYETHOXYLATED PYRAZOLO PYRIMIDINONE DERIVATIVES, PROCESS FOR PREPARATION THEREOF AND PHARMACEUTICAL COMPOSITIONS COMPRISING THE SAME FOR THE TREATMENT OF IMPOTENCE | LG LIFE SCIENCES LTD. (KR) | 2002-02-28 | — | — | WO | disclosed |
| WO-2001003644-A9 | PYRAZOLOPYRIMIDINONE DERIVATIVES CONJUGATED TO THIOPHENE MOIETIES OR BENZO [FUSED] 5-MEMBERED HETEROCYCLES FOR ERECTILE DYSFUNCTION | PICOWER INST MED RES (US) | 2001-11-29 | — | — | WO | disclosed |
| WO-2001022918-A2 | METHOD OF PREPARATION OF SILDENAFIL | INST FARMACEUTYCZNY (PL) | 2001-04-05 | — | — | WO | disclosed |
| EP-1085893-A1 | PHOSPHODIESTERASE-V MODULATOR DRUGS AND THEIR USES | Advanced Medicine, Inc. (US) | 2001-03-28 | — | — | EP | disclosed |
| WO-2001003644-A2 | PYRAZOLOPYRIMIDINONE DERIVATIVES CONJUGATED TO THIOPHENE MOIETIES OR BENZO [FUSED] 5-MEMBERED HETEROCYCLES FOR ERECTILE DYSFUNCTION | THE PICOWER INSTITUTE FOR MEDICAL RESEARCH (US) | 2001-01-18 | — | — | WO | disclosed |
| WO-1999064033-A9 | PHOSPHODIESTERASE-V MODULATOR DRUGS AND THEIR USES | ADVANCED MEDICINE INC (US) | 2000-07-27 | — | — | WO | disclosed |
| WO-1999064033-A1 | PHOSPHODIESTERASE-V MODULATOR DRUGS AND THEIR USES | ADVANCED MEDICINE, INC. (US) | 1999-12-16 | — | — | WO | disclosed |