Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.49 |
| ▸ | PPARA | Q07869 | 6/20 | 0.47 |
| ▸ | PPARD | Q03181 | 4/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | CA12 | O43570 | 1/20 | 0.46 |
| ▸ | CA1 | P00915 | 1/20 | 0.46 |
| ▸ | CA2 | P00918 | 1/20 | 0.46 |
| ▸ | CA4 | P22748 | 1/20 | 0.46 |
| ▸ | CA6 | P23280 | 1/20 | 0.46 |
| ▸ | CA7 | P43166 | 1/20 | 0.46 |
| ▸ | TPMT | P51580 | 1/20 | 0.46 |
| ▸ | CA9 | Q16790 | 1/20 | 0.46 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1960540 | 0.92 | MAPT (0.46) | MAPTPPARAPPARDKDM4EALDH1A1 | |
| SCHEMBL29664077 | 0.92 | MAPT (0.46) | MAPTPPARAPPARDKDM4EALDH1A1 | |
| SCHEMBL1960538 | 0.92 | MAPT (0.46) | MAPTPPARAPPARDKDM4EALDH1A1 | |
| SCHEMBL8511385 | 0.89 | ALDH1A1 (0.57) | MAPTPPARAKDM4EALDH1A1LMNA | |
| SCHEMBL8511383 | 0.89 | ALDH1A1 (0.57) | MAPTPPARAKDM4EALDH1A1LMNA | |
| SCHEMBL6131985 | 0.88 | CA12 (0.57) | MAPTALDH1A1CA12CA1CA2 | |
| SCHEMBL1331951 | 0.86 | CA12 (0.51) | MAPTPPARAKDM4EALDH1A1CA12 | |
| SCHEMBL1331949 | 0.86 | CA12 (0.51) | MAPTPPARAKDM4EALDH1A1CA12 | |
| SCHEMBL4367722 | 0.84 | SMPD1 (0.52) | MAPTALDH1A1CA12CA1CA2 | |
| SCHEMBL4367720 | 0.84 | SMPD1 (0.52) | MAPTALDH1A1CA12CA1CA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2078006-B1 | PHOTOCHROMIC MATERIALS DEMONSTRATING IMPROVED FADE RATES | TRANSITIONS OPTICAL INC (US) | 2018-11-07 | — | — | EP | disclosed |
| US-9006427-B2 | Photochromic materials demonstrating improved fade rates | TRANSITIONS OPTICAL, INC. (US) | 2015-04-14 | — | — | US | disclosed |
| US-8748634-B2 | Photochromic materials demonstrating improved fade rates | TRANSITIONS OPTICAL, INC. (US) | 2014-06-10 | — | — | US | disclosed |
| US-20140155598-A1 | PHOTOCHROMIC MATERIALS DEMONSTRATING IMPROVED FADE RATES | TRANSITIONS OPTICAL, INC. (US) | 2014-06-05 | — | — | US | disclosed |
| EP-2078006-A2 | PHOTOCHROMIC MATERIALS DEMONSTRATING IMPROVED FADE RATES | TRANSITIONS OPTICAL, INC. (US) | 2009-07-15 | — | — | EP | disclosed |
| WO-2008054942-A2 | PHOTOCHROMIC MATERIALS DEMONSTRATING IMPROVED FADE RATES | TRANSITIONS OPTICAL, INC. (US) | 2008-05-08 | — | — | WO | disclosed |
| US-20080103301-A1 | PHOTOCHROMIC MATERIALS DEMONSTRATING IMPROVED FADE RATES | TRANSITIONS OPTICAL, INC. (US) | 2008-05-01 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080103301-A1 | PHOTOCHROMIC MATERIALS DEMONSTRATING IMPROVED FADE RATES | PNPO, FLAD1, CRY2 | MAPT 1586/4885PPARA 715/4885PPARD 890/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.