Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 8/20 | 0.37 |
| ▸ | ADRA1D | P25100 | 7/20 | 0.37 |
| ▸ | ADRA1A | P35348 | 7/20 | 0.37 |
| ▸ | ADRA1B | P35368 | 7/20 | 0.37 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.35 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.35 |
| ▸ | HTR6 | P50406 | 1/20 | 0.35 |
| ▸ | DRD1 | P21728 | 1/20 | 0.33 |
| ▸ | DRD4 | P21917 | 1/20 | 0.33 |
| ▸ | DRD5 | P21918 | 1/20 | 0.33 |
| ▸ | DRD3 | P35462 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 3/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.33 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.33 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.33 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.33 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1014623 | 0.83 | PDE4B (0.47) | MEN1KMT2A | |
| SCHEMBL13210945 | 0.81 | HTR6 (0.38) | DRD2ADRA1DADRA1AADRA1BHCRTR1 | |
| Trifluoroacetic Acid SCHEMBL3961510 | 0.79 | HTR2A (0.41) | HTR6 | |
| SCHEMBL1012526 | 0.74 | HTR2A (0.47) | HTR6POLBTSHRMAPK1 | |
| SCHEMBL1014796 | 0.72 | STS (0.42) | — | |
| SCHEMBL1018308 | 0.69 | SMN1; SMN2 (0.45) | DRD2ADRA1DADRA1AADRA1BHTR6 | |
| SCHEMBL1018307 | 0.69 | SMN1; SMN2 (0.45) | DRD2ADRA1DADRA1AADRA1BHTR6 | |
| SCHEMBL1012384 | 0.69 | PDE4B (0.51) | HTR6 | |
| SCHEMBL1012382 | 0.69 | PDE4B (0.51) | HTR6 | |
| SCHEMBL1015948 | 0.69 | STS (0.55) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2081890-A1 | ARYLSULFONYL PYRROLIDINES AS 5-HT6 INHIBITORS | F. Hoffmann-Roche AG (CH) | 2009-07-29 | — | — | EP | disclosed |
| WO-2008055847-A1 | ARYLSULFONYL PYRROLIDINES AS 5-HT6 INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2008-05-15 | — | — | WO | disclosed |