Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 13/20 | 0.49 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | THRB | P10828 | 1/20 | 0.39 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.39 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.39 |
| ▸ | PTPN6 | P29350 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4476686 | 0.88 | KDM4E (0.46) | KDM4EALDH1A1HPGDNPSR1HTT | |
| SCHEMBL3959225 | 0.86 | CYP2C9 (0.37) | KDM4EALDH1A1NPSR1 | |
| SCHEMBL3962773 | 0.82 | GSK3B (0.43) | — | |
| SCHEMBL3959200 | 0.74 | GPR119 (0.43) | GPR119USP30KDM4E | |
| SCHEMBL4416230 | 0.71 | LATS1 (0.43) | — | |
| SCHEMBL4872195 | 0.71 | GSK3B (0.41) | — | |
| SCHEMBL2488011 | 0.70 | GPR119 (0.50) | GPR119USP30KDM4EALDH1A1HTT | |
| SCHEMBL13046433 | 0.70 | GSK3B (0.51) | GPR119USP30 | |
| SCHEMBL2488299 | 0.70 | USP30 (0.58) | GPR119USP30 | |
| SCHEMBL2529679 | 0.70 | GPR119 (0.50) | GPR119USP30 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2081938-A2 | SUBSTITUTED 8-PIPERIDINYL-2-PYRIDINYL-PYRIMIDO Ý1,2-A¨PIRIMIDIN-6-ONE AND 8-PIPERIDINYL-2-PYRIMIDI NYL-PYRIMIDOÝ1,2,-A¨PYRIMIDIN-6-ONE DERIVATIVES | Sanofi-Aventis (FR) | 2009-07-29 | — | — | EP | disclosed |
| WO-2008056266-A2 | SUBSTITUTED 8-PIPERIDINYL-2-PYRIDINYL-PYRIMIDO [1,2-A]PYRIMIDIN-6-ONE AND 8-PIPERIDINYL-2-PYRIMIDINYL-PYRIMIDO[1,2-A]PYRIMIDIN-6-ONE DERIVATIVES | SANOFI-AVENTIS (FR) | 2008-05-15 | — | — | WO | disclosed |