Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 3/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.47 |
| ▸ | PDE4B | Q07343 | 9/20 | 0.43 |
| ▸ | QDPR | P09417 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | PDE4A | P27815 | 1/20 | 0.41 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.41 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.41 |
| ▸ | DRD2 | P14416 | 1/20 | 0.40 |
| ▸ | DRD4 | P21917 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1014743 | 0.84 | PDE4B (0.57) | MEN1KMT2APDE4BMAPTPDE4A | |
| SCHEMBL13210893 | 0.77 | DRD2 (0.36) | MEN1KMT2AQDPRMAPTDRD2 | |
| SCHEMBL31386247 | 0.77 | PROKR1 (0.48) | MEN1KMT2AMAPTSMN1; SMN2 | |
| SCHEMBL28094425 | 0.76 | MEN1 (0.52) | MEN1KMT2APDE4BQDPRMAPT | |
| SCHEMBL2637185 | 0.72 | MEN1 (0.77) | MEN1KMT2AMAPTDRD2DRD4 | |
| SCHEMBL23326213 | 0.72 | PTGDR2 (0.57) | MEN1KMT2A | |
| SCHEMBL23326185 | 0.72 | HTR2A (0.55) | — | |
| SCHEMBL23326258 | 0.70 | ALDH1A1 (0.45) | NPC1MAPTRAB9ASMN1; SMN2 | |
| SCHEMBL26106200 | 0.70 | PDE4B (0.56) | PDE4BPDE4APDE4CPDE4D | |
| SCHEMBL1015417 | 0.70 | PDE4B (0.57) | MEN1KMT2APDE4BMAPTPDE4A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2081890-A1 | ARYLSULFONYL PYRROLIDINES AS 5-HT6 INHIBITORS | F. Hoffmann-Roche AG (CH) | 2009-07-29 | — | — | EP | disclosed |
| WO-2008055847-A1 | ARYLSULFONYL PYRROLIDINES AS 5-HT6 INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2008-05-15 | — | — | WO | disclosed |