Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | CHIT1 | Q13231 | 1/20 | 0.32 |
| ▸ | CHIA | Q9BZP6 | 1/20 | 0.32 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4828306 | 0.80 | SLC6A2 (0.38) | — | |
| SCHEMBL3953362 | 0.80 | OPRM1 (0.43) | — | |
| SCHEMBL3959432 | 0.77 | OPRM1 (0.40) | CHIT1CHIA | |
| SCHEMBL2984883 | 0.75 | OPRM1 (0.44) | — | |
| SCHEMBL2989048 | 0.75 | OPRM1 (0.44) | — | |
| SCHEMBL2986994 | 0.73 | ALDH1A1 (0.46) | HRH3 | |
| SCHEMBL4295611 | 0.73 | HRH3 (0.48) | LMNAHRH3 | |
| SCHEMBL2555848 | 0.72 | IDO1 (0.36) | — | |
| SCHEMBL14873238 | 0.72 | IDO1 (0.36) | — | |
| SCHEMBL14862307 | 0.72 | IDO1 (0.36) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2077837-A2 | DERIVATIVES OF PYRROLIZINE, INDOLIZINE AND QUINOLIZINE, PREPARATION THEREOF AND THERAPEUTIC USE THEREOF | Sanofi-Aventis (FR) | 2009-07-15 | — | — | EP | claimed |
| WO-2008037881-A2 | DERIVATIVES OF PYRROLIZINE, INDOLIZINE AND QUINOLIZINE, PREPARATION THEREOF AND THERAPEUTIC USE THEREOF | SANOFI-AVENTIS (FR) | 2008-04-03 | — | — | WO | claimed |
| EP-2077837-A2 | DERIVATIVES OF PYRROLIZINE, INDOLIZINE AND QUINOLIZINE, PREPARATION THEREOF AND THERAPEUTIC USE THEREOF | Sanofi-Aventis (FR) | 2009-07-15 | — | — | EP | disclosed |
| WO-2008037881-A2 | DERIVATIVES OF PYRROLIZINE, INDOLIZINE AND QUINOLIZINE, PREPARATION THEREOF AND THERAPEUTIC USE THEREOF | SANOFI-AVENTIS (FR) | 2008-04-03 | — | — | WO | disclosed |