Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR5A | P47898 | 1/20 | 0.53 |
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | GPR132 | Q9UNW8 | 1/20 | 0.39 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.39 |
| ▸ | HTR1A | P08908 | 1/20 | 0.39 |
| ▸ | DRD2 | P14416 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | CYSLTR1 | Q9Y271 | 5/20 | 0.38 |
| ▸ | GPBAR1 | Q8TDU6 | 1/20 | 0.38 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.37 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.37 |
| ▸ | BCHE | P06276 | 1/20 | 0.37 |
| ▸ | CYSLTR2 | Q9NS75 | 4/20 | 0.36 |
| ▸ | MAOA | P21397 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3962711 | 0.85 | HTR5A (0.55) | HTR5AMEN1KMT2AALDH1A1GPR132 | |
| SCHEMBL8199702 | 0.85 | HTR5A (0.55) | HTR5AMEN1KMT2AALDH1A1GPR132 | |
| SCHEMBL8200312 | 0.76 | CASR (0.65) | HTR5AMEN1KMT2AALDH1A1ABCB1 | |
| SCHEMBL4993611 | 0.76 | CASR (0.65) | HTR5AMEN1KMT2AALDH1A1ABCB1 | |
| SCHEMBL15131138 | 0.71 | MEN1 (0.56) | MEN1KMT2AALDH1A1BCHE | |
| SCHEMBL14197922 | 0.71 | MEN1 (0.65) | HTR5AMEN1KMT2AALDH1A1ABCB1 | |
| SCHEMBL2736162 | 0.70 | ALDH1A1 (0.53) | HTR5AMEN1KMT2AALDH1A1GPR132 | |
| SCHEMBL2760047 | 0.69 | ALDH1A1 (0.57) | HTR5AMEN1KMT2AALDH1A1GPR132 | |
| SCHEMBL8781060 | 0.69 | MEN1 (0.61) | HTR5AMEN1KMT2AALDH1A1SMN1; SMN2 | |
| SCHEMBL5269238 | 0.68 | MEN1 (0.60) | MEN1KMT2AALDH1A1BCHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2079525-A1 | CALCIUM RECEPTOR MODULATING AGENTS | Amgen Inc. (US) | 2009-07-22 | — | — | EP | disclosed |
| WO-2008057282-A1 | CALCIUM RECEPTOR MODULATING AGENTS | AMGEN INC. (US) | 2008-05-15 | — | — | WO | disclosed |