Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS1 | P23219 | 7/20 | 0.55 |
| ▸ | PTGS2 | P35354 | 7/20 | 0.55 |
| ▸ | MGLL | Q99685 | 7/20 | 0.50 |
| ▸ | FAAH | O00519 | 5/20 | 0.50 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.50 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
| ▸ | TP53 | P04637 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 1/20 | 0.50 |
| ▸ | PKM | P14618 | 1/20 | 0.50 |
| ▸ | HPGD | P15428 | 1/20 | 0.50 |
| ▸ | XBP1 | P17861 | 1/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.50 |
| ▸ | HTT | P42858 | 1/20 | 0.50 |
| ▸ | RECQL | P46063 | 1/20 | 0.50 |
| ▸ | RAB9A | P51151 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.50 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.50 |
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1887612 | 0.86 | PTGS1 (0.72) | PTGS1PTGS2MGLLFAAHHSP90AA1 | |
| SCHEMBL28698933 | 0.86 | PTGS1 (0.72) | PTGS1PTGS2MGLLFAAHHSP90AA1 | |
| SCHEMBL30180925 | 0.86 | PTGS1 (0.72) | PTGS1PTGS2MGLLFAAHHSP90AA1 | |
| SCHEMBL19817136 | 0.86 | PTGS1 (0.72) | PTGS1PTGS2MGLLFAAHHSP90AA1 | |
| SCHEMBL22398888 | 0.84 | PTGS1 (0.69) | PTGS1PTGS2MGLLFAAHHSP90AA1 | |
| Acetic Acid SCHEMBL27987918 | 0.80 | PTGS1 (0.69) | PTGS1PTGS2MGLLFAAHHSP90AA1 | |
| SCHEMBL1704532 | 0.79 | MGLL (0.62) | PTGS1PTGS2MGLLFAAHHSP90AA1 | |
| SCHEMBL21909660 | 0.76 | PTGS1 (0.64) | PTGS1PTGS2MGLLFAAHHSP90AA1 | |
| SCHEMBL1827739 | 0.76 | PTGS1 (0.51) | PTGS1PTGS2MGLLFAAHHSP90AA1 | |
| Trifluoroacetic Acid SCHEMBL30433783 | 0.76 | PTGS1 (0.63) | PTGS1PTGS2MGLLFAAHHSP90AA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105246894-A | Asymmetric pyrrolobenzodiazepine dimers for the treatment of proliferative and autoimmune diseases | SPIROGEN LTD | 2016-01-13 | — | — | CN | disclosed |
| US-20090270486-A1 | HUMAN RNASE III AND COMPOSITIONS AND USES THEREOF | ISIS PHARMACEUTICALS, INC. (US) | 2009-10-29 | — | — | US | disclosed |
| US-7491524-B2 | Human RNase III and compositions and uses thereof | ISIS PHARMACEUTICALS, INC. (US) | 2009-02-17 | — | — | US | disclosed |
| EP-1485400-A4 | HUMAN RNASE III AND COMPOSITIONS AND USES THEREOF | ISIS PHARMACEUTICALS INC (US) | 2005-11-30 | — | — | EP | disclosed |
| US-20050164234-A1 | Methods of using mammalian RNase H and compositions thereof | ISIS PHARMACEUTICALS, INC. | 2005-07-28 | — | — | US | disclosed |
| US-20050159384-A1 | Human RNase III and compositions and uses thereof | ISIS PHARMACEUTICALS, INC. (US) | 2005-07-21 | — | — | US | disclosed |
| WO-2005021776-A2 | METHODS OF USING MAMMALIAN RNase H AND COMPOSITIONS THEREOF | ISIS PHARMACEUTICALS, INC. (US) | 2005-03-10 | — | — | WO | disclosed |
| EP-1485400-A2 | HUMAN RNASE III AND COMPOSITIONS AND USES THEREOF | ISIS PHARMACEUTICALS, INC. (US) | 2004-12-15 | — | — | EP | disclosed |
| US-20040248145-A1 | Methods of using mammalian RNase H and compositions thereof | ISIS PHARMACEUTICALS, INC. | 2004-12-09 | — | — | US | disclosed |
| US-20040175828-A1 | Human RNase III and compositions and uses thereof | ISIS PHARMACEUTICALS, INC. | 2004-09-09 | — | — | US | disclosed |
| US-20040126867-A1 | Human RNase III and compositions and uses thereof | ISIS PHARMACEUTICALS, INC. | 2004-07-01 | — | — | US | disclosed |
| US-6737512-B2 | ENZYMATIC POLYPEPTIDE FOR USE IN THE TREATMENT OF INFECTIONS | ISIS PHARMACEUTICALS, INC. | 2004-05-18 | — | — | US | disclosed |
| WO-2003070904-A2 | HUMAN RNASE III AND COMPOSITIONS AND USES THEREOF | ISIS PHARMACEUTICALS, INC. (US) | 2003-08-28 | — | — | WO | disclosed |
| US-20030044941-A1 | Human RNase III and compositions and uses thereof | ISIS PHARMACEUTICALS, INC. | 2003-03-06 | — | — | US | disclosed |
| US-20020164601-A1 | Human RNase III and compositions and uses thereof | IONIS PHARMACEUTICALS, INC. | 2002-11-07 | — | — | US | disclosed |