Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR6 | P50406 | 18/20 | 0.67 |
| ▸ | HTR7 | P34969 | 1/20 | 0.52 |
| ▸ | HTR5A | P47898 | 1/20 | 0.52 |
| ▸ | HTR1A | P08908 | 1/20 | 0.43 |
| ▸ | HTR1D | P28221 | 1/20 | 0.43 |
| ▸ | HTR1B | P28222 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | ESR1 | P03372 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3959134 | 0.86 | HTR6 (0.76) | HTR6HTR7HTR5AHTR1AHTR1D | |
| SCHEMBL3961704 | 0.81 | HTR6 (0.80) | HTR6HTR7HTR5AHTR1AHTR1D | |
| SCHEMBL3961658 | 0.81 | HTR6 (0.73) | HTR6HTR7HTR5AHTR1AHTR1D | |
| SCHEMBL3964605 | 0.81 | HTR6 (0.79) | HTR6HTR7HTR5A | |
| SCHEMBL3155934 | 0.81 | HTR6 (0.82) | HTR6HTR7HTR5AHTR1AHTR1D | |
| SCHEMBL3147543 | 0.81 | HTR6 (1.00) | HTR6HTR7HTR5A | |
| SCHEMBL3957586 | 0.80 | HTR6 (0.77) | HTR6HTR7HTR5AHTR1AHTR1D | |
| SCHEMBL3966032 | 0.78 | HTR6 (0.73) | HTR6HTR7HTR5AHTR1AHTR1D | |
| SCHEMBL3965872 | 0.77 | HTR6 (0.75) | HTR6HTR7HTR5AHTR1AHTR1D | |
| SCHEMBL3148443 | 0.75 | HTR6 (0.82) | HTR6HTR7HTR5A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009036955-A1 | NAPHTYL-SUBSTITUTED SULFONAMIDES | LABORATORIOS DEL DR. ESTEVE, S.A. (ES) | 2009-03-26 | — | — | WO | disclosed |
| EP-2036888-A1 | Naphthyl-substituted sulfonamides | Laboratorios del Dr. Esteve S.A. (ES) | 2009-03-18 | — | — | EP | disclosed |