Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK1 | P06493 | 2/20 | 0.51 |
| ▸ | KDR | P35968 | 2/20 | 0.51 |
| ▸ | TBK1 | Q9UHD2 | 5/20 | 0.47 |
| ▸ | NUAK1 | O60285 | 3/20 | 0.47 |
| ▸ | NTRK1 | P04629 | 2/20 | 0.47 |
| ▸ | CSF1R | P07333 | 2/20 | 0.47 |
| ▸ | TYK2 | P29597 | 2/20 | 0.47 |
| ▸ | STK16 | O75716 | 1/20 | 0.47 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.47 |
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.47 |
| ▸ | ULK3 | Q6PHR2 | 1/20 | 0.47 |
| ▸ | BMP2K | Q9NSY1 | 1/20 | 0.47 |
| ▸ | IKBKE | Q14164 | 2/20 | 0.47 |
| ▸ | CDK2 | P24941 | 3/20 | 0.46 |
| ▸ | CCNA2 | P20248 | 2/20 | 0.46 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.46 |
| ▸ | CDK9 | P50750 | 1/20 | 0.46 |
| ▸ | JAK3 | P52333 | 2/20 | 0.46 |
| ▸ | JAK1 | P23458 | 1/20 | 0.46 |
| ▸ | AURKA | O14965 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3965218 | 0.90 | AXL (0.45) | CDK1KDRCDK2CCNA2JAK3 | |
| SCHEMBL3964134 | 0.82 | AXL (0.46) | CDK1KDRCDK2CCNA2JAK3 | |
| SCHEMBL3960892 | 0.79 | CCNT1 (0.61) | CDK1CDK2CCNA2CCNT1CDK9 | |
| SCHEMBL270735 | 0.77 | PLK4 (0.60) | CDK1KDRTBK1NUAK1NTRK1 | |
| SCHEMBL3971237 | 0.74 | AXL (0.53) | CDK1KDRCDK2CCNA2CCNT1 | |
| SCHEMBL13883490 | 0.74 | KCNH2 (0.46) | KDRTBK1CSF1RIKBKEJAK3 | |
| SCHEMBL3973039 | 0.74 | SRC (0.58) | KDRTBK1NUAK1NTRK1CSF1R | |
| SCHEMBL14536298 | 0.72 | TBK1 (0.67) | CDK1KDRTBK1NUAK1NTRK1 | |
| SCHEMBL3966018 | 0.72 | CCNT1 (0.42) | CDK1CDK2CCNA2CCNT1CDK9 | |
| SCHEMBL29370869 | 0.70 | CDK1 (0.63) | CDK1KDRTBK1NUAK1NTRK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009046416-A1 | ANILINOPYRIMIDINES AS JAK KINASE INHIBITORS | TARGEGEN INC. (US) | 2009-04-09 | — | — | WO | claimed |
| WO-2009046416-A1 | ANILINOPYRIMIDINES AS JAK KINASE INHIBITORS | TARGEGEN INC. (US) | 2009-04-09 | — | — | WO | disclosed |
| WO-2009046416-A1 | ANILINOPYRIMIDINES AS JAK KINASE INHIBITORS | TARGEGEN INC. (US) | 2009-04-09 | — | — | WO | disclosed |