Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AXL | P30530 | 4/20 | 0.53 |
| ▸ | CDK1 | P06493 | 4/20 | 0.46 |
| ▸ | KDR | P35968 | 4/20 | 0.46 |
| ▸ | AURKA | O14965 | 2/20 | 0.43 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.43 |
| ▸ | EGFR | P00533 | 2/20 | 0.42 |
| ▸ | JAK2 | O60674 | 4/20 | 0.42 |
| ▸ | JAK3 | P52333 | 3/20 | 0.42 |
| ▸ | CDK2 | P24941 | 3/20 | 0.42 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.41 |
| ▸ | CCNA2 | P20248 | 2/20 | 0.41 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.41 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.41 |
| ▸ | CDK9 | P50750 | 1/20 | 0.41 |
| ▸ | PLK4 | O00444 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13881583 | 0.92 | AXL (0.54) | AXLCDK1KDRJAK2JAK3 | |
| SCHEMBL4079587 | 0.88 | JAK2 (0.54) | CDK1JAK2JAK3CDK2CCNA2 | |
| SCHEMBL13881491 | 0.83 | AXL (0.44) | AXLCDK1KDRJAK2JAK3 | |
| SCHEMBL3969938 | 0.80 | AXL (0.56) | AXLKDRAURKAAURKBEGFR | |
| SCHEMBL3965218 | 0.78 | AXL (0.45) | AXLCDK1KDRAURKAAURKB | |
| SCHEMBL3966844 | 0.77 | AXL (0.47) | AXLEGFRJAK2JAK3CDK2 | |
| SCHEMBL13881457 | 0.77 | JAK2 (0.44) | AXLEGFRJAK2JAK3 | |
| SCHEMBL3969736 | 0.76 | AURKA (0.37) | AXLKDRAURKAJAK2CDK2 | |
| SCHEMBL13881489 | 0.75 | BRD4 (0.54) | AXLCDK1KDRAURKAAURKB | |
| SCHEMBL3963154 | 0.74 | CDK1 (0.51) | AXLCDK1KDRAURKAJAK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009046416-A1 | ANILINOPYRIMIDINES AS JAK KINASE INHIBITORS | TARGEGEN INC. (US) | 2009-04-09 | — | — | WO | disclosed |
| WO-2009046416-A1 | ANILINOPYRIMIDINES AS JAK KINASE INHIBITORS | TARGEGEN INC. (US) | 2009-04-09 | — | — | WO | disclosed |