Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH4 | Q9H3N8 | 2/20 | 0.54 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.48 |
| ▸ | PIK3CB | P42338 | 8/20 | 0.47 |
| ▸ | PIK3CA | P42336 | 3/20 | 0.46 |
| ▸ | TYK2 | P29597 | 2/20 | 0.45 |
| ▸ | SYK | P43405 | 2/20 | 0.45 |
| ▸ | IRAK4 | Q9NWZ3 | 2/20 | 0.45 |
| ▸ | BRSK1 | Q8TDC3 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.42 |
| ▸ | PKM | P14618 | 2/20 | 0.41 |
| ▸ | TSHR | P16473 | 2/20 | 0.41 |
| ▸ | CRHBP | P24387 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.41 |
| ▸ | FES | P07332 | 1/20 | 0.41 |
| ▸ | FER | P16591 | 1/20 | 0.41 |
| ▸ | FRK | P42685 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13906412 | 0.81 | HPGD (0.42) | HRH4L3MBTL1ALDH1A1KDM4EGAA | |
| SCHEMBL3957931 | 0.79 | L3MBTL1 (0.42) | HRH4L3MBTL1PIK3CBPIK3CAALDH1A1 | |
| SCHEMBL1377798 | 0.78 | TYK2 (0.64) | L3MBTL1PIK3CBTYK2SYKIRAK4 | |
| SCHEMBL914055 | 0.77 | MAPT (0.54) | L3MBTL1TYK2SYKIRAK4BRSK1 | |
| SCHEMBL26765746 | 0.69 | PIK3CB (0.60) | HRH4L3MBTL1PIK3CBPIK3CAGAA | |
| SCHEMBL3106397 | 0.69 | MEN1 (0.54) | ALDH1A1KDM4EGAAHTTLMNA | |
| SCHEMBL3558706 | 0.69 | PIK3CB (0.59) | HRH4PIK3CBPIK3CAKDM4EPIK3CD | |
| SCHEMBL10198704 | 0.68 | L3MBTL1 (0.56) | L3MBTL1TYK2SYKIRAK4ALDH1A1 | |
| SCHEMBL4035856 | 0.68 | TLR7 (0.49) | SMN1; SMN2LMNA | |
| SCHEMBL426317 | 0.68 | L3MBTL1 (0.56) | L3MBTL1TYK2SYKIRAK4ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009034386-A1 | DERIVATIVES OF ADENINE AND 8-AZA-ADENINE AND USES THEREOF-796 | ASTRAZENECA AB (SE) | 2009-03-19 | — | — | WO | disclosed |
| WO-2009034386-A1 | DERIVATIVES OF ADENINE AND 8-AZA-ADENINE AND USES THEREOF-796 | ASTRAZENECA AB (SE) | 2009-03-19 | — | — | WO | disclosed |