Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TLR7 | Q9NYK1 | 15/20 | 0.49 |
| ▸ | IL6 | P05231 | 7/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | STAT6 | P42226 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4040897 | 0.90 | TLR7 (0.50) | TLR7IL6 | |
| SCHEMBL3947510 | 0.84 | TLR7 (0.49) | TLR7IL6 | |
| SCHEMBL3954991 | 0.78 | PIK3C2B (0.50) | TLR7IL6LMNASTAT6SMN1; SMN2 | |
| SCHEMBL3961024 | 0.76 | TLR7 (0.46) | TLR7IL6LMNASTAT6SMN1; SMN2 | |
| SCHEMBL13274936 | 0.73 | TLR7 (0.67) | TLR7IL6 | |
| SCHEMBL13275562 | 0.71 | TLR7 (0.64) | TLR7IL6 | |
| SCHEMBL13906412 | 0.70 | HPGD (0.42) | TLR7LMNASMN1; SMN2 | |
| SCHEMBL1146212 | 0.70 | TLR7 (0.79) | TLR7IL6 | |
| SCHEMBL3957931 | 0.70 | L3MBTL1 (0.42) | LMNASMN1; SMN2 | |
| SCHEMBL13274361 | 0.70 | TLR7 (0.66) | TLR7IL6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009022185-A2 | 6, 6-FUSED HETEROCYCLES, THEIR PHARMACEUTICAL COMPOSITIONS AND METHOS OF USE | ASTRAZENECA AB (SE) | 2009-02-19 | — | — | WO | claimed |
| WO-2009022185-A2 | 6, 6-FUSED HETEROCYCLES, THEIR PHARMACEUTICAL COMPOSITIONS AND METHOS OF USE | ASTRAZENECA AB (SE) | 2009-02-19 | — | — | WO | disclosed |