Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 10/20 | 0.70 |
| ▸ | HPGD | P15428 | 5/20 | 0.70 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.70 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.70 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.70 |
| ▸ | POLB | P06746 | 2/20 | 0.70 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.70 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.70 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.70 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.70 |
| ▸ | CLK2 | P49760 | 1/20 | 0.70 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.70 |
| ▸ | LMNA | P02545 | 4/20 | 0.61 |
| ▸ | MEN1 | O00255 | 1/20 | 0.60 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.60 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.56 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.56 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.55 |
| ▸ | ATM | Q13315 | 1/20 | 0.54 |
| ▸ | GSK3B | P49841 | 2/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13841373 | 0.93 | KDM4E (0.60) | KDM4EHPGDALDH1A1KCNH2HSD17B10 | |
| SCHEMBL1859192 | 0.91 | KDM4E (0.57) | KDM4EHPGDALDH1A1KCNH2HSD17B10 | |
| Hydrochloric Acid SCHEMBL1857760 | 0.90 | KDM4E (0.57) | KDM4EHPGDALDH1A1KCNH2HSD17B10 | |
| SCHEMBL4715450 | 0.89 | KDM4E (0.62) | KDM4EHPGDALDH1A1KCNH2HSD17B10 | |
| SCHEMBL1155026 | 0.87 | KDM4E (0.80) | KDM4EHPGDALDH1A1KCNH2HSD17B10 | |
| Hydrochloric Acid SCHEMBL9751979 | 0.86 | KDM4E (0.79) | KDM4EHPGDALDH1A1KCNH2HSD17B10 | |
| SCHEMBL28079403 | 0.86 | KDM4E (0.79) | KDM4EHPGDALDH1A1KCNH2HSD17B10 | |
| Methyl Alcohol SCHEMBL29163210 | 0.86 | KDM4E (0.79) | KDM4EHPGDALDH1A1KCNH2HSD17B10 | |
| Water SCHEMBL28828205 | 0.86 | KDM4E (0.79) | KDM4EHPGDALDH1A1KCNH2HSD17B10 | |
| SCHEMBL27918942 | 0.86 | KDM4E (0.79) | KDM4EHPGDALDH1A1KCNH2HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7531656-B2 | Synthesis of gatifloxacin | TEVA PHARMACEUTICALS USA, INC. (US) | 2009-05-12 | — | — | US | disclosed |
| US-20080188658-A1 | Novel synthesis of gatifloxacin | TEVA PHARMACEUTICALS USA, INC. | 2008-08-07 | — | — | US | disclosed |
| US-20070072868-A1 | Novel synthesis of gatifloxacin | TEVA PHARMACEUTICAL INDUSTRIES LTD. | 2007-03-29 | — | — | US | disclosed |
| US-20050080264-A1 | Novel synthesis of gatifloxacin | TEVA PHARMACEUTICAL INDUSTRIES LTD. (IL) | 2005-04-14 | — | — | US | disclosed |
| EP-1478642-A1 | SYNTHESIS OF GATIFLOXACIN | TEVA PHARMACEUTICAL INDUSTRIES LTD. (IL) | 2004-11-24 | — | — | EP | disclosed |
| WO-2004069825-A1 | SYNTHESIS OF GATIFLOXACIN | TEVA PHARMACEUTICAL INDUSTRIES LTD. (IL) | 2004-08-19 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080188658-A1 | Novel synthesis of gatifloxacin | GATD3, ATIC, PDE7A | KDM4E 661/4885HPGD 1813/4885ALDH1A1 1962/4885 |
| US-20070072868-A1 | Novel synthesis of gatifloxacin | GATD3, ATIC, PDE7A | KDM4E 639/4885HPGD 1829/4885ALDH1A1 1963/4885 |
| US-20050080264-A1 | Novel synthesis of gatifloxacin | GATD3, ATIC, PDE7A | KDM4E 639/4885HPGD 1829/4885ALDH1A1 1963/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.