Sugi Predict

Sugi Predict / Compounds / SCHEMBL3963378

SCHEMBL3963378

SCHEMBL3963378

CCCCCCCC/C=C\CCCCCCCC(O)c1nc2c(C)cccc2o1

nearest known ligand 0.65

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
▸ FAAH O00519 7/20 0.45
▸ CES1 P23141 2/20 0.42
▸ DAGLA Q9Y4D2 2/20 0.40
▸ ALDH1A1 P00352 2/20 0.37
▸ MTOR P42345 1/20 0.37
▸ PMP22 Q01453 1/20 0.37
▸ SMN1; SMN2 Q16637 1/20 0.37
▸ CYP3A4 P08684 1/20 0.37
▸ CYP2C9 P11712 1/20 0.37
▸ ALOX15 P16050 1/20 0.37
▸ NFKB1 P19838 1/20 0.37
▸ KDM4E B2RXH2 1/20 0.37
▸ PLIN1 O60240 1/20 0.37
▸ GAA P10253 1/20 0.37
▸ MAPT P10636 1/20 0.37
▸ MAPK1 P28482 1/20 0.37
▸ PLIN5 Q00G26 1/20 0.37
▸ LTB4R Q15722 1/20 0.37
▸ ABHD5 Q8WTS1 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3956437 0.82 FAAH (0.59) FAAHCES1DAGLAALDH1A1MAPT
SCHEMBL3963222 0.81 FAAH (0.61) FAAHCES1DAGLAALDH1A1MTOR
SCHEMBL3963540 0.79 FAAH (0.66) FAAHCES1DAGLA
SCHEMBL3967501 0.79 FAAH (0.66) FAAHCES1DAGLA
SCHEMBL3964006 0.77 PDE5A (0.43) FAAHCES1KDM4EMAPTLTB4R
SCHEMBL3966149 0.77 FAAH (0.45) FAAHCES1DAGLALTB4R
SCHEMBL4221985 0.76 FAAH (0.70) FAAHCES1DAGLA
SCHEMBL3960857 0.74 FAAH (0.61) FAAHCES1
SCHEMBL3960885 0.74 FAAH (0.61) FAAHCES1DAGLA
SCHEMBL4302998 0.72 FAAH (0.61) FAAHCES1DAGLA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20090270421-A1 INHIBITORS OF FATTY ACID AMIDE HYDROLASE THE SCRIPPS RESEARCH INSTITUTE (US) 2009-10-29 — — US disclosed
US-7560570-B2 Inhibitors of fatty acid amide hydrolase THE SCRIPPS RESEARCH INSTITUTE (US) 2009-07-14 — — US disclosed
US-20050239785-A1 Inhibitors of fatty acid amide hydrolase THE SCRIPPS RESEARCH INSTITUTE (US) 2005-10-27 — — US disclosed
US-6891043-B2 Inhibitors of fatty acid amide hydrolase THE SCRIPPS RESEARCH INSTITUTE (US) 2005-05-10 — — US disclosed
US-20030092734-A1 Inhibitors of fatty acid amide hydrolase THE SCRIPPS RESEARCH INSTITUTE 2003-05-15 — — US disclosed
US-6462054-B1 ALPHA KETO HETEROCYCLIC PHARMACOPHORE; COMPLEMENTARY BINDING BY ELECTROPHILIC CARBONYL AND WEAKLY BASIC NITROGEN OF SUCH AS OXAZOLOPYRIDINE GROUP; SLEEP AIDS OR ANALGESICS; PRESERVING ENDOGENOUS LEVELS OF OLEAMIDE AND ANANDAMIDE THE SCRIPPS RESEARCH INSTITUTE 2002-10-08 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20090270421-A1 INHIBITORS OF FATTY ACID AMIDE HYDROLASE FAAH, FAAH2, CNR2 FAAH 1/4885CES1 23/4885DAGLA 131/4885
US-20030092734-A1 Inhibitors of fatty acid amide hydrolase FAAH, FAAH2, CNR2 FAAH 1/4885CES1 9/4885DAGLA 202/4885
US-20050239785-A1 Inhibitors of fatty acid amide hydrolase FAAH, FAAH2, CNR2 FAAH 1/4885CES1 23/4885DAGLA 131/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.