Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TLR4 | O00206 | 1/20 | 0.47 |
| ▸ | TLR2 | O60603 | 1/20 | 0.47 |
| ▸ | PARP15 | Q460N3 | 3/20 | 0.45 |
| ▸ | PARP10 | Q53GL7 | 3/20 | 0.45 |
| ▸ | MAOA | P21397 | 2/20 | 0.44 |
| ▸ | MAOB | P27338 | 2/20 | 0.44 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.44 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.44 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16151158 | 0.86 | CYP2D6 (0.45) | CHRNB4CHRNA3 | |
| SCHEMBL4568824 | 0.86 | CHRNB4 (0.47) | TLR4TLR2PARP15PARP10MAOA | |
| SCHEMBL25820645 | 0.84 | CHRNB4 (0.46) | TLR4TLR2PARP15PARP10MAOA | |
| SCHEMBL13881607 | 0.84 | CHRNB4 (0.46) | TLR4TLR2PARP15PARP10MAOA | |
| SCHEMBL4568821 | 0.84 | CHRNA3 (0.51) | TLR4TLR2PARP15PARP10MAOA | |
| SCHEMBL2204534 | 0.83 | TLR4 (0.45) | TLR4TLR2PARP15PARP10CHRNB4 | |
| SCHEMBL2206912 | 0.81 | CHRNB4 (0.56) | TLR4TLR2PARP15PARP10CHRNB4 | |
| SCHEMBL2208539 | 0.81 | CHRNB4 (0.48) | TLR4TLR2PARP15PARP10CHRNB4 | |
| SCHEMBL19291385 | 0.81 | CHRNB4 (0.48) | TLR4TLR2PARP15PARP10CHRNB4 | |
| SCHEMBL4569107 | 0.77 | TLR4 (0.52) | TLR4TLR2PARP15PARP10MAOA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2091955-A1 | ALKOXY COMPOUNDS FOR DISEASE TREATMENT | Acucela, Inc. (US) | 2009-08-26 | — | — | EP | disclosed |
| WO-2009045479-A1 | ALKOXY COMPOUNDS FOR DISEASE TREATMENT | ACUCELA INC. (US) | 2009-04-09 | — | — | WO | disclosed |