Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KEAP1 | Q14145 | 2/20 | 0.53 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.44 |
| ▸ | ASPH | Q12797 | 3/20 | 0.44 |
| ▸ | KDM8 | Q8N371 | 2/20 | 0.44 |
| ▸ | NAPRT | Q6XQN6 | 1/20 | 0.41 |
| ▸ | ALB | P02768 | 2/20 | 0.38 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.36 |
| ▸ | AKR1C1 | Q04828 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.33 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.33 |
| ▸ | ACMSD | Q8TDX5 | 2/20 | 0.33 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.33 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | AURKA | O14965 | 1/20 | 0.33 |
| ▸ | DHODH | Q02127 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7535033 | 0.83 | KEAP1 (0.50) | KEAP1NFE2L2KDM4EASPHKDM8 | |
| SCHEMBL7591627 | 0.81 | KEAP1 (0.48) | KEAP1NFE2L2KDM4EASPHKDM8 | |
| SCHEMBL19679344 | 0.81 | KEAP1 (0.75) | KEAP1NFE2L2KDM4EASPHKDM8 | |
| SCHEMBL6837965 | 0.78 | KDM4E (0.41) | KEAP1NFE2L2KDM4EASPHKDM8 | |
| SCHEMBL1300386 | 0.78 | KEAP1 (0.41) | KEAP1NFE2L2KDM4EASPHKDM8 | |
| SCHEMBL8564557 | 0.77 | KEAP1 (0.44) | KEAP1NFE2L2KDM4EASPHKDM8 | |
| SCHEMBL1301581 | 0.75 | KEAP1 (0.39) | KEAP1NFE2L2KDM4EASPHKDM8 | |
| SCHEMBL7858377 | 0.75 | NPC1 (0.41) | KDM4ENPC1RAB9AALDH1A1TSHR | |
| SCHEMBL3960162 | 0.75 | MAPT (0.41) | KEAP1NFE2L2KDM4EALDH1A1CYP1A2 | |
| SCHEMBL4830274 | 0.75 | KEAP1 (0.54) | KEAP1NFE2L2KDM4EASPHKDM8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2014023531-A1 | TRIFLUOROMETHYLPYRIDINE CARBOXAMIDES AS PESTICIDES | SYNGENTA PARTICIPATIONS AG (CH) | 2014-02-13 | — | — | WO | disclosed |
| EP-2079734-A1 | OXADIAZOLE AND THIADIAZOLE COMPOUNDS AND THEIR USE AS NICOTINIC ACETYLCHOLINE RECEPTOR MODULATORS | NeuroSearch A/S (DK) | 2009-07-22 | — | — | EP | disclosed |
| WO-2008049864-A1 | OXADIAZOLE AND THIADIAZOLE COMPOUNDS AND THEIR USE AS NICOTINIC ACETYLCHOLINE RECEPTOR MODULATORS | NEUROSEARCH A/S (DK) | 2008-05-02 | — | — | WO | disclosed |