Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TAAR1 | Q96RJ0 | 3/20 | 0.49 |
| ▸ | SLC2A1 | P11166 | 4/20 | 0.47 |
| ▸ | PNMT | P11086 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | RECQL | P46063 | 1/20 | 0.38 |
| ▸ | CASR | P41180 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | HAT1 | O14929 | 1/20 | 0.38 |
| ▸ | EP300 | Q09472 | 1/20 | 0.38 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.38 |
| ▸ | AOC3 | Q16853 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8192497 | 0.76 | CASR (0.46) | SLC2A1ALDH1A1SMN1; SMN2CASRCYP2D6 | |
| SCHEMBL3963876 | 0.76 | CASR (0.46) | SLC2A1ALDH1A1SMN1; SMN2CASRCYP2D6 | |
| SCHEMBL3963878 | 0.76 | TAAR1 (0.54) | TAAR1KMT2AMEN1ALDH1A1HPGD | |
| SCHEMBL12000669 | 0.76 | TAAR1 (0.66) | TAAR1SLC2A1PNMTKMT2AMEN1 | |
| Hydrochloric Acid SCHEMBL16930403 | 0.74 | NOS1 (0.66) | TAAR1SLC2A1 | |
| SCHEMBL31424066 | 0.70 | CASR (0.67) | SLC2A1CASR | |
| SCHEMBL8162339 | 0.70 | CASR (0.67) | SLC2A1CASR | |
| SCHEMBL15130942 | 0.70 | CASR (0.67) | SLC2A1CASR | |
| SCHEMBL6221598 | 0.70 | CASR (0.67) | SLC2A1CASR | |
| SCHEMBL3961413 | 0.69 | KMT2A (0.67) | KMT2AMEN1ALDH1A1HPGDSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2079525-A1 | CALCIUM RECEPTOR MODULATING AGENTS | Amgen Inc. (US) | 2009-07-22 | — | — | EP | disclosed |
| WO-2008057282-A1 | CALCIUM RECEPTOR MODULATING AGENTS | AMGEN INC. (US) | 2008-05-15 | — | — | WO | disclosed |