Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TAAR1 | Q96RJ0 | 3/20 | 0.54 |
| ▸ | NOS1 | P29475 | 4/20 | 0.53 |
| ▸ | NOS3 | P29474 | 2/20 | 0.53 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.52 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.51 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.51 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.51 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.51 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.49 |
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.47 |
| ▸ | NOS2 | P35228 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | PKM | P14618 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3963109 | 0.78 | GAA (0.56) | HDAC1CYP1A2CYP3A4CYP2D6CYP2C19 | |
| SCHEMBL3963877 | 0.76 | TAAR1 (0.49) | TAAR1HDAC1CYP2D6CYP2C19ALDH1A1 | |
| SCHEMBL3961413 | 0.76 | KMT2A (0.67) | HDAC1ALDH1A1KMT2AMEN1HPGD | |
| SCHEMBL13911270 | 0.75 | TAAR1 (0.68) | TAAR1NOS1NOS3HDAC1CYP1A2 | |
| SCHEMBL12652039 | 0.75 | TAAR1 (0.62) | TAAR1NOS1NOS3HDAC1CYP1A2 | |
| SCHEMBL19352860 | 0.74 | SIGMAR1 (0.62) | TAAR1NOS1NOS3HDAC1CYP1A2 | |
| SCHEMBL13995331 | 0.73 | TAAR1 (0.60) | TAAR1NOS1NOS3HDAC1CYP1A2 | |
| SCHEMBL3963736 | 0.73 | CYP1A2 (0.55) | TAAR1NOS1NOS3HDAC1CYP1A2 | |
| SCHEMBL16562026 | 0.72 | TAAR1 (0.69) | TAAR1CYP1A2CYP3A4CYP2D6CYP2C19 | |
| SCHEMBL2473716 | 0.71 | TAAR1 (0.62) | TAAR1NOS1NOS3HDAC1CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2079525-A1 | CALCIUM RECEPTOR MODULATING AGENTS | Amgen Inc. (US) | 2009-07-22 | — | — | EP | disclosed |
| WO-2008057282-A1 | CALCIUM RECEPTOR MODULATING AGENTS | AMGEN INC. (US) | 2008-05-15 | — | — | WO | disclosed |