Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CNR2 | P34972 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | GRN | P28799 | 1/20 | 0.45 |
| ▸ | SORT1 | Q99523 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 3/20 | 0.42 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.42 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.42 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.42 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.42 |
| ▸ | ATM | Q13315 | 1/20 | 0.41 |
| ▸ | PHGDH | O43175 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | THRB | P10828 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3964900 | 0.88 | KDM4E (0.43) | KDM4EGRNSORT1MAPTPHGDH | |
| SCHEMBL3963914 | 0.87 | CNR2 (0.47) | CNR2KDM4EGRNSORT1MAPT | |
| SCHEMBL1465025 | 0.78 | CNR2 (0.64) | CNR2MAPTMAPK13MAPK12MAPK11 | |
| SCHEMBL3968969 | 0.78 | ATM (0.41) | MAPTATMALDH1A1LMNAGAA | |
| SCHEMBL3963604 | 0.77 | MAPT (0.43) | KDM4EMAPTATMALDH1A1LMNA | |
| SCHEMBL3959595 | 0.76 | CNR1 (0.47) | CNR2MAPTATMALDH1A1LMNA | |
| SCHEMBL351726 | 0.75 | EEF2K (0.58) | KDM4EMAPTATMALDH1A1LMNA | |
| SCHEMBL352072 | 0.75 | GRN (0.71) | CNR2KDM4EGRNSORT1MAPT | |
| SCHEMBL7744788 | 0.74 | GRN (0.67) | CNR2KDM4EGRNSORT1MAPT | |
| SCHEMBL3965097 | 0.72 | CNR2 (0.45) | CNR2MAPTATMALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2081905-A2 | SULFONYL COMPOUNDS WHICH MODULATE THE CB2 RECEPTOR | Boehringer Ingelheim International GmbH (DE) | 2009-07-29 | — | — | EP | disclosed |
| WO-2008014199-A2 | SULFONYL COMPOUNDS WHICH MODULATE THE CB2 RECEPTOR | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2008-01-31 | — | — | WO | disclosed |