Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRN | P28799 | 5/20 | 0.67 |
| ▸ | SORT1 | Q99523 | 5/20 | 0.67 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.67 |
| ▸ | NPC1 | O15118 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 3/20 | 0.49 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.49 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.49 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.49 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.49 |
| ▸ | CNR2 | P34972 | 3/20 | 0.48 |
| ▸ | CNR1 | P21554 | 2/20 | 0.42 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | CTSL | P07711 | 2/20 | 0.40 |
| ▸ | CTSS | P25774 | 2/20 | 0.40 |
| ▸ | CTSV | O60911 | 1/20 | 0.40 |
| ▸ | CTSB | P07858 | 1/20 | 0.40 |
| ▸ | CTSK | P43235 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| 4-Chloroaniline SCHEMBL7744796 | 0.87 | GRN (0.70) | GRNSORT1KDM4ENPC1MAPT | |
| SCHEMBL1572486 | 0.82 | GRN (1.00) | GRNSORT1KDM4ENPC1MAPT | |
| SCHEMBL7744333 | 0.81 | GRN (0.76) | GRNSORT1NPC1MAPT | |
| Hydrochloric Acid SCHEMBL8760885 | 0.80 | GRN (0.96) | GRNSORT1KDM4ENPC1MAPT | |
| SCHEMBL352072 | 0.77 | GRN (0.71) | GRNSORT1KDM4EMAPTMAPK13 | |
| SCHEMBL3963913 | 0.74 | CNR2 (0.46) | GRNSORT1KDM4EMAPTMAPK13 | |
| SCHEMBL1903709 | 0.74 | MAPT (0.68) | GRNSORT1KDM4ENPC1MAPT | |
| SCHEMBL7739174 | 0.72 | GRN (0.76) | GRNSORT1NPC1MAPT | |
| SCHEMBL350765 | 0.71 | GRN (0.71) | GRNSORT1KDM4EMAPTMAPK13 | |
| SCHEMBL7744751 | 0.69 | RAB9A (0.51) | NPC1MAPTMAP4K4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1252156-A1 | BLOCKADE OF VOLTAGE DEPENDENT SODIUM CHANNELS | University College London (GB) | 2002-10-30 | — | — | EP | claimed |
| WO-2001057024-A1 | BLOCKADE OF VOLTAGE DEPENDENT SODIUM CHANNELS | UNIVERSITY COLLEGE LONDON (GB) | 2001-08-09 | — | — | WO | claimed |