Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | STK4 | Q13043 | 1/20 | 0.34 |
| ▸ | STK3 | Q13188 | 1/20 | 0.34 |
| ▸ | PTGER4 | P35408 | 2/20 | 0.31 |
| ▸ | PRKD1 | Q15139 | 1/20 | 0.31 |
| ▸ | PRKD2 | Q9BZL6 | 1/20 | 0.31 |
| ▸ | SCD | O00767 | 1/20 | 0.31 |
| ▸ | JAK1 | P23458 | 1/20 | 0.31 |
| ▸ | JAK3 | P52333 | 1/20 | 0.31 |
| ▸ | NPC1 | O15118 | 1/20 | 0.30 |
| ▸ | RAB9A | P51151 | 1/20 | 0.30 |
| ▸ | CD38 | P28907 | 1/20 | 0.30 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.30 |
| ▸ | BDKRB1 | P46663 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3965808 | 0.89 | PIK3CB (0.37) | STK4STK3PTGER4PRKD2JAK1 | |
| SCHEMBL4193391 | 0.88 | AURKA (0.33) | PRKD1PRKD2NPC1RAB9ACD38 | |
| SCHEMBL3740333 | 0.76 | AURKA (0.39) | PRKD1PRKD2NPC1RAB9A | |
| SCHEMBL3744921 | 0.76 | BTK (0.43) | JAK1JAK3 | |
| SCHEMBL3750774 | 0.75 | NPC1 (0.42) | STK4STK3NPC1RAB9A | |
| SCHEMBL3753112 | 0.73 | ACVR1 (0.39) | STK4STK3NPC1RAB9A | |
| SCHEMBL3964701 | 0.69 | BTK (0.45) | — | |
| SCHEMBL3968942 | 0.66 | BTK (0.51) | — | |
| SCHEMBL3747925 | 0.65 | BTK (0.42) | — | |
| SCHEMBL3744929 | 0.65 | BTK (0.43) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2079726-A2 | SUBSTITUTED AMIDES, METHOD OF MAKING, AND METHOD OF USE THEREOF | CGI Pharmaceuticals, Inc. (US) | 2009-07-22 | — | — | EP | disclosed |
| WO-2008033857-A2 | SUBSTITUTED AMIDES, METHOD OF MAKING, AND METHOD OF USE THEREOF | CGI PHARMACEUTICALS, INC. (US) | 2008-03-20 | — | — | WO | disclosed |