Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BTK | Q06187 | 19/20 | 0.45 |
| ▸ | KIT | P10721 | 1/20 | 0.38 |
| ▸ | SRC | P12931 | 1/20 | 0.38 |
| ▸ | FLT3 | P36888 | 1/20 | 0.38 |
| ▸ | ITK | Q08881 | 1/20 | 0.38 |
| ▸ | BMX | P51813 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1321885 | 0.80 | BTK (0.67) | BTK | |
| SCHEMBL3957050 | 0.79 | BTK (0.55) | BTKSRCFLT3ITKBMX | |
| SCHEMBL3960170 | 0.79 | BTK (0.56) | BTKKITSRCFLT3ITK | |
| SCHEMBL3967674 | 0.78 | BTK (0.53) | BTKKITSRCFLT3ITK | |
| SCHEMBL3958013 | 0.77 | BTK (0.46) | BTKKITSRCFLT3ITK | |
| SCHEMBL3961204 | 0.76 | BTK (0.52) | BTKSRCFLT3ITKBMX | |
| SCHEMBL3953323 | 0.75 | BTK (0.51) | BTKKITSRCFLT3ITK | |
| SCHEMBL171471 | 0.75 | BTK (0.67) | BTKKITSRCFLT3ITK | |
| SCHEMBL3658579 | 0.73 | BTK (0.55) | BTKKITSRCFLT3ITK | |
| SCHEMBL1322858 | 0.69 | BTK (0.85) | BTK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2081923-A1 | CERTAIN SUBSTITUTED AMIDES, METHOD OF MAKING, AND METHOD OF USE THEREOF | CGI Pharmaceuticals, Inc. (US) | 2009-07-29 | — | — | EP | disclosed |
| WO-2008033854-A1 | CERTAIN SUBSTITUTED AMIDES, METHOD OF MAKING, AND METHOD OF USE THEREOF | CGI PHARMACEUTICALS, INC. (US) | 2008-03-20 | — | — | WO | disclosed |