Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AURKA | O14965 | 2/20 | 0.33 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.33 |
| ▸ | BDKRB1 | P46663 | 1/20 | 0.33 |
| ▸ | EZH1 | Q92800 | 2/20 | 0.33 |
| ▸ | EZH2 | Q15910 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 3/20 | 0.33 |
| ▸ | RAB9A | P51151 | 3/20 | 0.33 |
| ▸ | PARP1 | P09874 | 4/20 | 0.32 |
| ▸ | PARP2 | Q9UGN5 | 2/20 | 0.32 |
| ▸ | KIT | P10721 | 1/20 | 0.32 |
| ▸ | PRKD1 | Q15139 | 1/20 | 0.31 |
| ▸ | PRKD2 | Q9BZL6 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | HPGD | P15428 | 1/20 | 0.31 |
| ▸ | KDR | P35968 | 1/20 | 0.31 |
| ▸ | MT-CO2 | P00403 | 1/20 | 0.31 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.30 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3965808 | 0.90 | PIK3CB (0.37) | AURKAAURKBNPC1RAB9APRKD2 | |
| SCHEMBL3963945 | 0.88 | STK4 (0.34) | BDKRB1NPC1RAB9APRKD1PRKD2 | |
| SCHEMBL3740333 | 0.78 | AURKA (0.39) | AURKAAURKBNPC1RAB9APARP1 | |
| SCHEMBL3757117 | 0.76 | BTK (0.43) | — | |
| SCHEMBL3750774 | 0.76 | NPC1 (0.42) | NPC1RAB9AKDM4E | |
| SCHEMBL3753112 | 0.72 | ACVR1 (0.39) | NPC1RAB9APARP1 | |
| SCHEMBL3745143 | 0.67 | BTK (0.41) | — | |
| SCHEMBL3749975 | 0.67 | BTK (0.41) | — | |
| SCHEMBL3968942 | 0.66 | BTK (0.51) | AURKAAURKB | |
| SCHEMBL3740338 | 0.66 | AURKA (0.37) | AURKAAURKBNPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2079726-A2 | SUBSTITUTED AMIDES, METHOD OF MAKING, AND METHOD OF USE THEREOF | CGI Pharmaceuticals, Inc. (US) | 2009-07-22 | — | — | EP | disclosed |
| WO-2008033857-A2 | SUBSTITUTED AMIDES, METHOD OF MAKING, AND METHOD OF USE THEREOF | CGI PHARMACEUTICALS, INC. (US) | 2008-03-20 | — | — | WO | disclosed |