Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDGFRB | P09619 | 7/20 | 0.71 |
| ▸ | PDPK1 | O15530 | 5/20 | 0.71 |
| ▸ | KDR | P35968 | 8/20 | 0.68 |
| ▸ | FLT3 | P36888 | 6/20 | 0.68 |
| ▸ | RET | P07949 | 5/20 | 0.68 |
| ▸ | CHEK1 | O14757 | 4/20 | 0.68 |
| ▸ | JAK3 | P52333 | 3/20 | 0.68 |
| ▸ | AURKB | Q96GD4 | 3/20 | 0.68 |
| ▸ | TLK2 | Q86UE8 | 3/20 | 0.68 |
| ▸ | FLT1 | P17948 | 3/20 | 0.68 |
| ▸ | ALK | Q9UM73 | 3/20 | 0.68 |
| ▸ | DAPK3 | O43293 | 2/20 | 0.68 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.68 |
| ▸ | NTRK1 | P04629 | 2/20 | 0.68 |
| ▸ | LCK | P06239 | 2/20 | 0.68 |
| ▸ | CSF1R | P07333 | 2/20 | 0.68 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.68 |
| ▸ | LTK | P29376 | 2/20 | 0.68 |
| ▸ | RPS6KA3 | P51812 | 2/20 | 0.68 |
| ▸ | MAP2K1 | Q02750 | 2/20 | 0.68 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL396431 | 1.00 | PDGFRB (0.71) | PDGFRBPDPK1KDRFLT3RET | |
| SCHEMBL5728408 | 0.89 | PDPK1 (0.76) | PDGFRBPDPK1KDRFLT3RET | |
| SCHEMBL5728405 | 0.89 | PDPK1 (0.76) | PDGFRBPDPK1KDRFLT3RET | |
| SCHEMBL5728610 | 0.83 | PDPK1 (0.80) | PDGFRBPDPK1KDRFLT3RET | |
| SCHEMBL5728251 | 0.83 | PDGFRB (1.00) | PDGFRBPDPK1KDRFLT3RET | |
| SCHEMBL5728248 | 0.83 | PDGFRB (1.00) | PDGFRBPDPK1KDRFLT3RET | |
| SCHEMBL5728607 | 0.83 | PDPK1 (0.80) | PDGFRBPDPK1KDRFLT3RET | |
| SCHEMBL5728403 | 0.83 | PDGFRB (0.80) | PDGFRBPDPK1KDRFLT3RET | |
| SCHEMBL5728402 | 0.83 | PDGFRB (0.80) | PDGFRBPDPK1KDRFLT3RET | |
| SCHEMBL5728570 | 0.83 | PDPK1 (1.00) | PDGFRBPDPK1KDRFLT3RET |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8101608-B2 | 3-(4-Methyl-imidazol-1-yl)-N-{3-[2-oxo-3-(1H-pyrrol-2-ylmethylene)-2,3-dihydro-1H-indol-6-ylamino]-phenyl}-5-trifluoromethyl-benzamide; including benign and malignant proliferative disorders as well as diseases resulting from inappropriate activation of the immune and nervous systems | IRM LLC, a Delware Limited Corporation (BM) | 2012-01-24 | — | — | US | disclosed |
| EP-1814545-A4 | COMPOUNDS AND COMPOSITIONS AS PROTEIN KINASE INHIBITORS | IRM LLC (BM) | 2009-06-10 | — | — | EP | disclosed |
| US-20080221192-A1 | Compounds and Compositions as Protein Kinase Inhibitors | IRM LLC (BM) | 2008-09-11 | — | — | US | disclosed |
| EP-1814545-A2 | COMPOUNDS AND COMPOSITIONS AS PROTEIN KINASE INHIBITORS | IRM, LLC (BM) | 2007-08-08 | — | — | EP | disclosed |
| WO-2006052936-A2 | COMPOUNDS AND COMPOSITIONS AS PROTEIN KINASE INHIBITORS | IRM LLC (BM) | 2006-05-18 | — | — | WO | disclosed |
| US-6797825-B2 | 1,3-DIHYDRO-2H-INDOL- 2-ONE DERIVATIVES | ABBOTT LABORATORIES | 2004-09-28 | — | — | US | disclosed |
| US-20030162785-A1 | Protein kinase inhibitors | ABBVIE INC. | 2003-08-28 | — | — | US | disclosed |
| US-20030119839-A1 | Protein kinase inhibitors | ABBOTT LABORATORIES | 2003-06-26 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030162785-A1 | Protein kinase inhibitors | MAP3K20, MAP3K1, MAP3K6 | PDGFRB 766/4885PDPK1 90/4885KDR 1241/4885 |
| US-20080221192-A1 | Compounds and Compositions as Protein Kinase Inhibitors | BMX, FRK, PTK2B | PDGFRB 313/4885PDPK1 370/4885KDR 204/4885 |
| US-20030119839-A1 | Protein kinase inhibitors | MAP3K20, MAP3K1, MAP3K6 | PDGFRB 766/4885PDPK1 90/4885KDR 1241/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.