Known targets — ChEMBL curated mechanism
ACHEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3APH1AAPH1BCHRM2CHRM3EZH2GRIN2AHTR1AHTR1BHTR1DHTR1FHTR3ANCSTNP2RY12PSEN1PSEN2PSENENSIGMAR1SLC6A2SLC6A3SLC6A4
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | CA12 | O43570 | 3/20 | 0.43 |
| ▸ | CA1 | P00915 | 3/20 | 0.43 |
| ▸ | CA2 | P00918 | 3/20 | 0.43 |
| ▸ | CA9 | Q16790 | 3/20 | 0.43 |
| ▸ | GRM3 | Q14832 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.39 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2878783 | 0.98 | ALDH1A1 (0.49) | ALDH1A1TSHRHPGDCA12CA1 | |
| SCHEMBL2880648 | 0.98 | ALDH1A1 (0.49) | ALDH1A1TSHRHPGDCA12CA1 | |
| SCHEMBL316646 | 0.98 | ALDH1A1 (0.49) | ALDH1A1TSHRHPGDCA12CA1 | |
| SCHEMBL7357706 | 0.92 | ALDH1A1 (0.48) | ALDH1A1TSHRHPGDCA12CA1 | |
| SCHEMBL2875175 | 0.85 | NOTUM (0.46) | ALDH1A1MAPT | |
| SCHEMBL2875954 | 0.85 | NOTUM (0.46) | ALDH1A1MAPT | |
| SCHEMBL652433 | 0.85 | NOTUM (0.46) | ALDH1A1MAPT | |
| SCHEMBL25363482 | 0.82 | ALDH1A1 (0.57) | ALDH1A1TSHRCA12CA1CA2 | |
| SCHEMBL6831699 | 0.82 | ALDH1A1 (0.51) | ALDH1A1TSHRHPGDCA12CA1 | |
| SCHEMBL3179327 | 0.82 | ALDH1A1 (0.46) | ALDH1A1TSHRHPGDCA12CA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009033689-A1 | PIPERIDONE DERIVATIVES AND MEDICAL USES THEREOF | HEINRICH-PETTE-INSTITUT (DE) | 2009-03-19 | — | — | WO | disclosed |