Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Sulfalene. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.90 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.90 |
| ▸ | ESR1 | P03372 | 1/20 | 0.63 |
| ▸ | GAA | P10253 | 2/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.54 |
| ▸ | CCR4 | P51679 | 3/20 | 0.52 |
| ▸ | LMNA | P02545 | 3/20 | 0.51 |
| ▸ | MAPT | P10636 | 1/20 | 0.51 |
| ▸ | ALOX12 | P18054 | 2/20 | 0.49 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.48 |
| ▸ | AURKA | O14965 | 1/20 | 0.48 |
| ▸ | DHFR | P00374 | 1/20 | 0.48 |
| ▸ | TSHR | P16473 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Sulfalene SCHEMBL28404 | 0.95 | MEN1 (1.00) | MEN1KMT2AESR1GAAALDH1A1 | |
| Sulfalene SCHEMBL1893333 | 0.95 | MEN1 (1.00) | MEN1KMT2AESR1GAAALDH1A1 | |
| Sulfalene SCHEMBL28086248 | 0.90 | MEN1 (0.90) | MEN1KMT2AESR1GAAALDH1A1 | |
| Sulfalene SCHEMBL3961075 | 0.88 | KMT2A (0.87) | MEN1KMT2AESR1GAAALDH1A1 | |
| Sulfadoxine SCHEMBL28122268 | 0.85 | ESR1 (0.88) | MEN1KMT2AESR1GAAALDH1A1 | |
| Sulfalene SCHEMBL28122260 | 0.82 | KMT2A (0.76) | MEN1KMT2AESR1GAAALDH1A1 | |
| Sulfalene SCHEMBL28766577 | 0.81 | KMT2A (0.74) | MEN1KMT2AESR1GAAALDH1A1 | |
| Sulfalene SCHEMBL28263603 | 0.81 | MEN1 (0.74) | MEN1KMT2AESR1GAAALDH1A1 | |
| SCHEMBL1095077 | 0.80 | KMT2A (0.74) | MEN1KMT2AESR1GAAALDH1A1 | |
| Sulfadimethoxine SCHEMBL28086139 | 0.80 | ALDH1A1 (0.77) | MEN1KMT2AESR1GAAALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-107827864-B | Method for separating chemical components of methylene chloride extraction part of piper longum composition and application | 宁夏医科大学 | 2020-02-07 | — | — | CN | disclosed |
| WO-2009041786-A2 | PHARMACEUTICAL COMPOSITION COMPRISING INHIBITORS OF CELL ADHESION MOLECULE ISOLATED FROM PIPER LONGUM FOR THE PREVENTION AND TREATMENT OF INFLAMMATORY DISEASE | KOREA RESEARCH INSTITUTE OF BIOSCIENCE AND BIOTECHNOLOGY (KR) | 2009-04-02 | — | — | WO | disclosed |