Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Sulfalene. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.90 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.90 |
| ▸ | ESR1 | P03372 | 1/20 | 0.63 |
| ▸ | GAA | P10253 | 2/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.54 |
| ▸ | CA1 | P00915 | 1/20 | 0.52 |
| ▸ | CA2 | P00918 | 1/20 | 0.52 |
| ▸ | HTT | P42858 | 1/20 | 0.52 |
| ▸ | CA9 | Q16790 | 1/20 | 0.52 |
| ▸ | LMNA | P02545 | 3/20 | 0.51 |
| ▸ | MAPT | P10636 | 1/20 | 0.51 |
| ▸ | ALOX12 | P18054 | 2/20 | 0.49 |
| ▸ | CCR4 | P51679 | 2/20 | 0.49 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.48 |
| ▸ | AURKA | O14965 | 1/20 | 0.48 |
| ▸ | DHFR | P00374 | 1/20 | 0.48 |
| ▸ | TSHR | P16473 | 1/20 | 0.48 |
| ▸ | PIK3C2B | O00750 | 1/20 | 0.46 |
| ▸ | PIK3C2G | O75747 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Sulfalene SCHEMBL28404 | 0.95 | MEN1 (1.00) | MEN1KMT2AESR1GAAALDH1A1 | |
| Sulfalene SCHEMBL1893333 | 0.95 | MEN1 (1.00) | MEN1KMT2AESR1GAAALDH1A1 | |
| Sulfalene SCHEMBL3964512 | 0.90 | MEN1 (0.90) | MEN1KMT2AESR1GAAALDH1A1 | |
| Sulfalene SCHEMBL3961075 | 0.88 | KMT2A (0.87) | MEN1KMT2AESR1GAAALDH1A1 | |
| Sulfadoxine SCHEMBL28122268 | 0.85 | ESR1 (0.88) | MEN1KMT2AESR1GAAALDH1A1 | |
| Sulfadoxine SCHEMBL615997 | 0.84 | ESR1 (0.90) | MEN1KMT2AESR1ALDH1A1CA1 | |
| Sulfalene SCHEMBL28122260 | 0.82 | KMT2A (0.76) | MEN1KMT2AESR1GAAALDH1A1 | |
| Sulfalene SCHEMBL28263603 | 0.81 | MEN1 (0.74) | MEN1KMT2AESR1GAAALDH1A1 | |
| Sulfalene SCHEMBL28766577 | 0.81 | KMT2A (0.74) | MEN1KMT2AESR1GAAALDH1A1 | |
| SCHEMBL10695768 | 0.81 | MEN1 (0.58) | MEN1KMT2AGAAALDH1A1CA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-103492389-B | Pyrazolo [4,3-d] pyrimidine as inhibitors of kinases | 原真股份有限公司 | 2016-09-14 | — | — | CN | disclosed |