Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BTK | Q06187 | 12/20 | 0.56 |
| ▸ | BDKRB1 | P46663 | 1/20 | 0.39 |
| ▸ | KIT | P10721 | 3/20 | 0.38 |
| ▸ | SRC | P12931 | 3/20 | 0.38 |
| ▸ | FLT3 | P36888 | 3/20 | 0.38 |
| ▸ | ITK | Q08881 | 3/20 | 0.38 |
| ▸ | AURKA | O14965 | 1/20 | 0.38 |
| ▸ | TTK | P33981 | 1/20 | 0.38 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.38 |
| ▸ | INCENP | Q9NQS7 | 1/20 | 0.38 |
| ▸ | BMX | P51813 | 1/20 | 0.38 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3967674 | 0.88 | BTK (0.53) | BTKKITSRCFLT3ITK | |
| SCHEMBL3963771 | 0.85 | BTK (0.45) | BTKBMX | |
| SCHEMBL3957050 | 0.83 | BTK (0.55) | BTKBDKRB1SRCFLT3ITK | |
| SCHEMBL3961204 | 0.81 | BTK (0.52) | BTKBDKRB1SRCFLT3ITK | |
| SCHEMBL1321819 | 0.80 | BTK (0.86) | BTK | |
| SCHEMBL3964701 | 0.79 | BTK (0.45) | BTKKITSRCFLT3ITK | |
| SCHEMBL3958013 | 0.79 | BTK (0.46) | BTKKITSRCFLT3ITK | |
| SCHEMBL3953323 | 0.77 | BTK (0.51) | BTKKITSRCFLT3ITK | |
| SCHEMBL3658579 | 0.74 | BTK (0.55) | BTKKITSRCFLT3ITK | |
| SCHEMBL1322473 | 0.72 | BTK (1.00) | BTK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2081923-A1 | CERTAIN SUBSTITUTED AMIDES, METHOD OF MAKING, AND METHOD OF USE THEREOF | CGI Pharmaceuticals, Inc. (US) | 2009-07-29 | — | — | EP | disclosed |
| WO-2008033854-A1 | CERTAIN SUBSTITUTED AMIDES, METHOD OF MAKING, AND METHOD OF USE THEREOF | CGI PHARMACEUTICALS, INC. (US) | 2008-03-20 | — | — | WO | disclosed |