Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP4K4 | O95819 | 7/20 | 0.42 |
| ▸ | MPO | P05164 | 1/20 | 0.39 |
| ▸ | PI4KA | P42356 | 3/20 | 0.37 |
| ▸ | PI4K2B | Q8TCG2 | 3/20 | 0.37 |
| ▸ | PI4K2A | Q9BTU6 | 3/20 | 0.37 |
| ▸ | PI4KB | Q9UBF8 | 3/20 | 0.37 |
| ▸ | IGF1R | P08069 | 2/20 | 0.37 |
| ▸ | PKM | P14618 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | PPP1CA | P62136 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16487299 | 0.83 | TAAR1 (0.44) | MAP4K4MPOPI4KAPI4K2BPI4K2A | |
| SCHEMBL11014112 | 0.81 | LRRK2 (0.39) | MPOLRRK2 | |
| SCHEMBL870860 | 0.78 | PI4KA (0.52) | MAP4K4PI4KAPI4K2BPI4K2API4KB | |
| SCHEMBL21170713 | 0.75 | MAP4K4 (0.41) | MAP4K4PI4KAPI4K2BPI4K2API4KB | |
| SCHEMBL16487159 | 0.74 | XIAP (0.38) | MAP4K4PI4KAPI4K2BPI4K2API4KB | |
| SCHEMBL16487031 | 0.74 | MAP4K4 (0.45) | MAP4K4PI4KAPI4K2BPI4K2API4KB | |
| SCHEMBL5066797 | 0.72 | PI4KA (0.43) | MAP4K4PI4KAPI4K2BPI4K2API4KB | |
| SCHEMBL5045443 | 0.71 | HSP90AA1 (0.53) | MAP4K4MPOPI4KAPI4K2BPI4K2A | |
| SCHEMBL3652806 | 0.71 | FEN1 (0.34) | MPOIGF1RPKMNPSR1NPC1 | |
| SCHEMBL6683145 | 0.70 | PI4KA (0.42) | MAP4K4PI4KAPI4K2BPI4K2API4KB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009034386-A1 | DERIVATIVES OF ADENINE AND 8-AZA-ADENINE AND USES THEREOF-796 | ASTRAZENECA AB (SE) | 2009-03-19 | — | — | WO | disclosed |