SCHEMBL3965140

SCHEMBL3965140

CSc1ncc(OC(F)F)cc1C

nearest known ligand 0.32

Predicted protein targets (top 10)

geneUniProtsupporting neighboursconfidence
F2RL3 Q96RI0 1/20 0.32
PIK3CA P42336 1/20 0.31
RXRA P19793 1/20 0.30
GRIN1 Q05586 1/20 0.30
GRIN2B Q13224 1/20 0.30
KCNH2 Q12809 1/20 0.30
LMNA P02545 1/20 0.30
GAA P10253 1/20 0.30
BACE1 P56817 5/20 0.30
CTSD P07339 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL24588076 0.78 MBOAT4 (0.36) F2RL3PIK3CARXRAGRIN1GRIN2B
SCHEMBL18679972 0.75 LMNA (0.34) PIK3CALMNAGAABACE1CTSD
SCHEMBL15900430 0.75 GAA (0.37) LMNAGAABACE1
SCHEMBL15201659 0.75 PIK3CA (0.32) F2RL3PIK3CARXRAGRIN1GRIN2B
SCHEMBL1551098 0.72 MEN1 (0.33) RXRAGRIN1GRIN2B
SCHEMBL362114 0.71 ADORA2A (0.37) PIK3CARXRAGRIN1GRIN2BKCNH2
SCHEMBL3969722 0.70 MEN1 (0.36) PIK3CALMNABACE1CTSD
SCHEMBL363130 0.70 BACE1 (0.42) BACE1CTSD
SCHEMBL2178393 0.69
SCHEMBL16461418 0.69 BACE1 (0.46) BACE1CTSD

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2078721-B1 Thieno-pyrimidine compounds having fungicidal activity DOW AGROSCIENCES LLC (US) 2014-01-22 EP disclosed
EP-2078721-A2 Thieno-pyrimidime compounds having fungicidal activity Dow AgroSciences LLC (US) 2009-07-15 EP disclosed
US-7531482-B2 Thieno-pyrimidine compounds having fungicidal activity DOW AGROSCIENCES LLC (US) 2009-05-12 US disclosed
EP-1937691-A1 THIENO-PYRIMIDINE COMPOUNDS HAVING FUNGICIDAL ACTIVITY Dow Agrosciences LLC (US) 2008-07-02 EP disclosed
US-20070093498-A1 Thieno-pyrimidine compounds having fungicidal activity BREWSTER WILLIAM K 2007-04-26 US disclosed
WO-2007046809-A1 THIENO-PYRIMIDINE COMPOUNDS HAVING FUNGICIDAL ACTIVITY DOW AGROSCIENCES LLC (US) 2007-04-26 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20070093498-A1 Thieno-pyrimidine compounds having fungicidal activity TYMP, DPM1, TYMS F2RL3 2808/4885PIK3CA 872/4885RXRA 2701/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.