SCHEMBL396536

SCHEMBL396536

C=C(C)C(=O)OCC(O[Si](C)(C)C)[SiH2]O

nearest known ligand 0.52

Predicted protein targets (top 3)

geneUniProtsupporting neighboursconfidence
TSHR P16473 3/20 0.52
ALDH1A1 P00352 2/20 0.39
THRB P10828 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1943351 0.80 TSHR (0.57) TSHRALDH1A1THRB
SCHEMBL3949551 0.79 TSHR (0.66) TSHRALDH1A1THRB
SCHEMBL395896 0.73 TSHR (0.49) TSHRALDH1A1THRB
SCHEMBL29011426 0.73 TSHR (0.45) TSHRALDH1A1THRB
SCHEMBL393526 0.72 TSHR (0.43) TSHRALDH1A1THRB
SCHEMBL545329 0.72 TSHR (0.47) TSHRALDH1A1THRB
SCHEMBL642807 0.72 TSHR (0.44) TSHRALDH1A1THRB
SCHEMBL147268 0.71 TSHR (0.71) TSHRALDH1A1THRB
SCHEMBL2562319 0.71 TSHR (0.59) TSHRALDH1A1THRB
SCHEMBL8356574 0.70 TSHR (0.45) TSHRALDH1A1THRB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8110697-B2 Method for the production of polymerizable silicones WACKER CHEMIE AG (DE) 2012-02-07 US disclosed
US-8101789-B2 Method for the production of polymerizable silicones WACKER CHEMIE AG (DE) 2012-01-24 US disclosed
EP-2125833-B1 METHOD FOR THE PRODUCTION OF POLYMERISABLE SILICONES WACKER CHEMIE AG (DE) 2010-08-25 EP disclosed
EP-2125834-B1 METHOD FOR THE PRODUCTION OF POLYMERISABLE SILICONES WACKER CHEMIE AG (DE) 2010-08-25 EP disclosed
US-20100041909-A1 METHOD FOR THE PRODUCTION OF POLYMERIZABLE SILICONES WACKER CHEMIE AG (DE) 2010-02-18 US disclosed
US-20100029972-A1 METHOD FOR THE PRODUCTION OF POLYMERIZABLE SILICONES WACKER CHEMIE AG (DE) 2010-02-04 US disclosed