Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE10A | Q9Y233 | 2/20 | 0.41 |
| ▸ | CSF1R | P07333 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | TSHR | P16473 | 2/20 | 0.38 |
| ▸ | PKM | P14618 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 2/20 | 0.37 |
| ▸ | USP2 | O75604 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | SMPD3 | Q9NY59 | 1/20 | 0.36 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.35 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | PIM1 | P11309 | 3/20 | 0.35 |
| ▸ | PIM3 | Q86V86 | 2/20 | 0.35 |
| ▸ | PIM2 | Q9P1W9 | 2/20 | 0.35 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.34 |
| ▸ | MTOR | P42345 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 2/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3535973 | 0.82 | HTR3A (0.49) | CSF1RKMT2AMEN1TSHRPKM | |
| SCHEMBL3535733 | 0.81 | MAPT (0.53) | PDE10AKMT2AMEN1MAPTLMNA | |
| SCHEMBL2068144 | 0.78 | PDE10A (0.41) | PDE10AOPRM1OPRL1PIM1PIM3 | |
| SCHEMBL3544978 | 0.71 | CSF1R (0.79) | CSF1R | |
| SCHEMBL31297185 | 0.69 | PIK3CA (0.42) | PDE10AOPRM1OPRL1PIM1PIM3 | |
| SCHEMBL3540736 | 0.69 | ALDH1A1 (0.55) | CSF1RKMT2AMEN1TSHRMAPT | |
| SCHEMBL3534730 | 0.69 | ALDH1A1 (0.50) | CSF1RKMT2AMEN1TSHRMAPT | |
| SCHEMBL25188971 | 0.68 | MEN1 (0.47) | KMT2AMEN1TSHRPKMGAA | |
| SCHEMBL2442050 | 0.68 | GRIN2D (0.51) | PDE10AOPRM1OPRL1PIM1PIM3 | |
| SCHEMBL3542448 | 0.68 | KMT2A (0.42) | KMT2AMEN1TSHRPKMGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1807407-B1 | AROMATIC AMIDES AS INHIBITORS OF C-FMS KINASE | JANSSEN PHARMACEUTICA NV (BE) | 2009-07-29 | — | — | EP | claimed |