Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.32 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.32 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.30 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.30 |
| ▸ | TSHR | P16473 | 1/20 | 0.30 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.30 |
| ▸ | MAPT | P10636 | 1/20 | 0.30 |
| ▸ | APEX1 | P27695 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL3971166 | 0.98 | SIRT2 (0.31) | SIRT2SIRT1 | |
| SCHEMBL3970057 | 0.86 | CYP3A4 (0.32) | CYP3A4TSHRTDP1MAPTAPEX1 | |
| SCHEMBL4077712 | 0.86 | SIRT1 (0.35) | SIRT2SIRT1EPHX1MAPT | |
| Hydrochloric Acid SCHEMBL3971562 | 0.84 | CYP3A4 (0.31) | CYP3A4TSHRTDP1MAPTAPEX1 | |
| SCHEMBL29264295 | 0.77 | SIRT1 (0.31) | SIRT2SIRT1EPHX1 | |
| SCHEMBL4078350 | 0.76 | EPHX1 (0.32) | SIRT2SIRT1EPHX1MAPT | |
| SCHEMBL4958424 | 0.75 | — | — | |
| SCHEMBL27345212 | 0.74 | — | — | |
| SCHEMBL19400484 | 0.70 | — | — | |
| SCHEMBL21964325 | 0.70 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009049018-A1 | NOVEL COMPOUNDS AND METHODS OF USING THEM | SYNDAX PHARMACEUTICALS, INC. (US) | 2009-04-16 | — | — | WO | disclosed |
| WO-2009049018-A1 | NOVEL COMPOUNDS AND METHODS OF USING THEM | SYNDAX PHARMACEUTICALS, INC. (US) | 2009-04-16 | — | — | WO | disclosed |