SCHEMBL3966352

SCHEMBL3966352

O=Cc1cccc(Sc2ccc(F)cc2)c1

nearest known ligand 0.47

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAOA P21397 3/20 0.46
MAOB P27338 3/20 0.46
ALDH1A1 P00352 3/20 0.41
NFE2L2 Q16236 3/20 0.39
HDAC3 O15379 1/20 0.39
HDAC4 P56524 1/20 0.39
HDAC1 Q13547 1/20 0.39
HDAC7 Q8WUI4 1/20 0.39
HDAC2 Q92769 1/20 0.39
HDAC10 Q969S8 1/20 0.39
HDAC11 Q96DB2 1/20 0.39
HDAC8 Q9BY41 1/20 0.39
HDAC6 Q9UBN7 1/20 0.39
HDAC9 Q9UKV0 1/20 0.39
HDAC5 Q9UQL6 1/20 0.39
NPY5R Q15761 1/20 0.39
UNG P13051 1/20 0.38
TERT O14746 1/20 0.38
ANXA2 P07355 1/20 0.37
S100A10 P60903 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29572439 1.00 MAOA (0.46) MAOAMAOBALDH1A1NFE2L2HDAC3
SCHEMBL6848984 0.87 ALDH1A1 (0.47) MAOAMAOBALDH1A1HDAC3HDAC4
SCHEMBL6852138 0.87 ALDH1A1 (0.52) MAOAMAOBALDH1A1HDAC3HDAC4
SCHEMBL31618073 0.85 ALDH1A1 (0.52) MAOAMAOBALDH1A1HDAC3HDAC4
SCHEMBL1681164 0.85 ALDH1A1 (0.52) MAOAMAOBALDH1A1HDAC3HDAC4
SCHEMBL5321387 0.82 HSD17B10 (0.47) MAOAMAOBALDH1A1HDAC3HDAC4
SCHEMBL2541321 0.82 CYP2A6 (0.47) MAOAMAOBALDH1A1NFE2L2HDAC3
SCHEMBL2244675 0.81 ALDH1A1 (0.38) MAOBALDH1A1HDAC3HDAC4HDAC1
SCHEMBL1465620 0.81 ALDH1A1 (0.52) ALDH1A1NFE2L2MEN1KMT2AMAPT
SCHEMBL6255853 0.78 NPC1 (0.52) MAOBALDH1A1NFE2L2HDAC3HDAC4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-110835335-B 2, 5-diketopiperazine compound and application thereof in preparation of anti-cancer drugs 深圳华大海洋科技有限公司 2022-04-15 CN disclosed
CN-110835335-A 2, 5-diketopiperazine compound and application thereof in preparation of anti-cancer drugs 青岛海洋生物医药研究院股份有限公司 2020-02-25 CN disclosed
WO-2009044147-A1 INDOLIZINE DERIVATIVES WITH CRTH2 RECEPTOR AFFINITY FOR THE TREATMENT OF INFLAMMATORY DISEASES ARGENTA DISCOVERY LIMITED (GB) 2009-04-09 WO disclosed
EP-0636119-B1 PHENYL SUBSTITUTED CYCLOALKYL HYDROXYUREA DERIVATIVES WHICH INHIBIT LIPOXYGENASE PFIZER (US) 1997-11-05 EP disclosed
EP-0736006-A1 PHENYLTHIOPHENYL CYCLOALKENYL HYDROXYUREAS AS LIPOXYGENASE INHIBITORS PFIZER INC. (US) 1996-10-09 EP disclosed
WO-1995017379-A1 PHENYLTHIOPHENYL CYCLOALKENYL HYDROXYUREAS AS LIPOXYGENASE INHIBITORS PFIZER INC. (US) 1995-06-29 WO disclosed
EP-0636119-A1 PHENYL SUBSTITUTED CYCLOALKYL HYDROXYUREA DERIVATIVES WHICH INHIBIT LIPOXYGENASE PFIZER INC. (US) 1995-02-01 EP disclosed
WO-1993021149-A1 PHENYL SUBSTITUTED CYCLOALKYL HYDROXYUREA DERIVATIVES WHICH INHIBIT LIPOXYGENASE PFIZER INC. (US) 1993-10-28 WO disclosed