Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK1 | P06493 | 2/20 | 0.42 |
| ▸ | KDR | P35968 | 2/20 | 0.42 |
| ▸ | IKBKB | O14920 | 5/20 | 0.41 |
| ▸ | CHUK | O15111 | 4/20 | 0.41 |
| ▸ | IKBKG | Q9Y6K9 | 4/20 | 0.41 |
| ▸ | ACP1 | P24666 | 3/20 | 0.40 |
| ▸ | PRKCQ | Q04759 | 1/20 | 0.39 |
| ▸ | PRKCD | Q05655 | 1/20 | 0.39 |
| ▸ | HRH3 | Q9Y5N1 | 4/20 | 0.39 |
| ▸ | JAK1 | P23458 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | RECQL | P46063 | 1/20 | 0.38 |
| ▸ | BLM | P54132 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | PRKCZ | Q05513 | 1/20 | 0.38 |
| ▸ | LTA4H | P09960 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13883504 | 0.91 | TTK (0.45) | KDRACP1PRKCQPRKCDHRH3 | |
| Hydrochloric Acid SCHEMBL3974362 | 0.90 | TTK (0.44) | KDRACP1PRKCQPRKCDHRH3 | |
| SCHEMBL3966481 | 0.84 | BACE1 (0.48) | KDRIKBKBCHUKIKBKGHRH3 | |
| SCHEMBL13883557 | 0.81 | IKBKB (0.40) | IKBKBCHUKIKBKGJAK1L3MBTL1 | |
| SCHEMBL13883724 | 0.81 | AXL (0.47) | PRKCQPRKCDTTK | |
| SCHEMBL3967492 | 0.81 | MAPK1 (0.41) | CDK1KDRACP1HRH3JAK1 | |
| SCHEMBL3970201 | 0.81 | MAPK1 (0.41) | CDK1KDRACP1HRH3JAK1 | |
| SCHEMBL3970857 | 0.80 | TTK (0.45) | KDRPRKCQPRKCDTTK | |
| SCHEMBL3969173 | 0.80 | TTK (0.40) | CDK1KDRACP1JAK1MAPK1 | |
| SCHEMBL3970156 | 0.79 | TTK (0.61) | JAK1TTK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009049028-A1 | PYRROLOPYRIMIDINE COMPOUNDS AND THEIR USE AS JANUS KINASE MODULATORS | TARGEGEN INC. (US) | 2009-04-16 | — | — | WO | disclosed |
| WO-2009049028-A1 | PYRROLOPYRIMIDINE COMPOUNDS AND THEIR USE AS JANUS KINASE MODULATORS | TARGEGEN INC. (US) | 2009-04-16 | — | — | WO | disclosed |