Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.57 |
| ▸ | SYK | P43405 | 1/20 | 0.56 |
| ▸ | BRAF | P15056 | 1/20 | 0.52 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.51 |
| ▸ | JAK2 | O60674 | 3/20 | 0.51 |
| ▸ | JAK3 | P52333 | 3/20 | 0.51 |
| ▸ | AXL | P30530 | 2/20 | 0.50 |
| ▸ | BACE1 | P56817 | 4/20 | 0.49 |
| ▸ | EGFR | P00533 | 1/20 | 0.49 |
| ▸ | INSR | P06213 | 1/20 | 0.49 |
| ▸ | IGF1R | P08069 | 1/20 | 0.49 |
| ▸ | MET | P08581 | 1/20 | 0.49 |
| ▸ | CDK2 | P24941 | 1/20 | 0.49 |
| ▸ | KDR | P35968 | 1/20 | 0.49 |
| ▸ | TEK | Q02763 | 1/20 | 0.49 |
| ▸ | SRC | P12931 | 2/20 | 0.48 |
| ▸ | AIMP2 | Q13155 | 1/20 | 0.48 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.48 |
| ▸ | ABL1 | P00519 | 2/20 | 0.47 |
| ▸ | BCR | P11274 | 2/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3973092 | 0.82 | SRC (0.65) | HRH3SYKBRAFJAK2JAK3 | |
| SCHEMBL3963672 | 0.81 | AXL (0.60) | HRH3SYKBRAFKCNH2JAK2 | |
| SCHEMBL4254804 | 0.80 | AXL (0.64) | HRH3BRAFJAK2JAK3AXL | |
| SCHEMBL4074376 | 0.78 | HRH3 (0.62) | HRH3BRAFJAK2JAK3AXL | |
| SCHEMBL7466134 | 0.78 | MEN1 (0.62) | SYKCDK2KDRSRCPTK2 | |
| SCHEMBL12109533 | 0.78 | HRH3 (0.77) | HRH3SYKBRAFJAK2JAK3 | |
| SCHEMBL3969268 | 0.77 | HRH3 (0.46) | HRH3BRAFKCNH2JAK2JAK3 | |
| SCHEMBL31025683 | 0.77 | HRH3 (0.56) | HRH3KCNH2LTA4H | |
| SCHEMBL14140330 | 0.76 | AIMP2 (0.54) | SYKEGFRAIMP2ABL1BCR | |
| SCHEMBL12278133 | 0.76 | HRH3 (0.69) | HRH3SYKBRAFJAK2JAK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009046416-A1 | ANILINOPYRIMIDINES AS JAK KINASE INHIBITORS | TARGEGEN INC. (US) | 2009-04-09 | — | — | WO | claimed |
| WO-2009046416-A1 | ANILINOPYRIMIDINES AS JAK KINASE INHIBITORS | TARGEGEN INC. (US) | 2009-04-09 | — | — | WO | disclosed |
| WO-2009046416-A1 | ANILINOPYRIMIDINES AS JAK KINASE INHIBITORS | TARGEGEN INC. (US) | 2009-04-09 | — | — | WO | disclosed |