Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA2 | P00918 | 7/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | CA1 | P00915 | 4/20 | 0.45 |
| ▸ | SLC1A3 | P43003 | 1/20 | 0.40 |
| ▸ | SLC1A2 | P43004 | 1/20 | 0.40 |
| ▸ | SLC1A1 | P43005 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 4/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | HPGD | P15428 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | FAAH | O00519 | 1/20 | 0.39 |
| ▸ | GRIK1 | P39086 | 2/20 | 0.37 |
| ▸ | GRIK2 | Q13002 | 2/20 | 0.37 |
| ▸ | CPA1 | P15085 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5363929 | 0.87 | CHRM1 (0.46) | CA2MAPK1SLC1A3SLC1A2SLC1A1 | |
| SCHEMBL5067753 | 0.86 | CA2 (0.46) | CA2MAPK1CA1SLC1A3SLC1A2 | |
| SCHEMBL570260 | 0.86 | CA2 (0.61) | CA2MAPK1CA1SLC1A3SLC1A2 | |
| SCHEMBL2081268 | 0.86 | CA2 (0.61) | CA2MAPK1CA1SLC1A3SLC1A2 | |
| SCHEMBL5805533 | 0.84 | CA2 (0.44) | CA2MAPK1CA1SLC1A3SLC1A2 | |
| SCHEMBL8572261 | 0.84 | CA2 (0.59) | CA2MAPK1CA1SLC1A3SLC1A2 | |
| SCHEMBL5197384 | 0.84 | CA2 (0.44) | CA2MAPK1CA1SLC1A3SLC1A2 | |
| SCHEMBL28191059 | 0.84 | CA2 (0.62) | CA2MAPK1CA1SLC1A3SLC1A2 | |
| SCHEMBL8567555 | 0.84 | CA2 (0.59) | CA2MAPK1CA1SLC1A3SLC1A2 | |
| SCHEMBL8572256 | 0.82 | CA2 (0.58) | CA2MAPK1CA1SLC1A3SLC1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 28 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5786071-A | Method of preparation of polyquinolines | HITACHI CHEMICAL COMPANY, LTD. (JP) | 1998-07-28 | — | — | US | claimed |
| CN-111808044-B | Green synthesis method for efficiently synthesizing aminothiazole derivative through carbene insertion/cyclization reaction under catalysis of transition metal | 四川大学 | 2022-10-21 | — | — | CN | disclosed |
| CN-111808044-A | Novel green synthesis method for efficiently synthesizing aminothiazole derivative through carbene insertion/cyclization reaction under catalysis of transition metal | 四川大学 | 2020-10-23 | — | — | CN | disclosed |
| CN-102558231-B | Ophthalmic compositions for treating ocular hypertension | MERCK & CO INC | 2015-05-27 | — | — | CN | disclosed |
| EP-1562909-B1 | OPHTHALMIC COMPOSITIONS FOR TREATING OCULAR HYPERTENSION | MERCK SHARP & DOHME (US) | 2012-06-27 | — | — | EP | disclosed |
| US-7547720-B2 | Ophthalmic compositions for treating ocular hypertension | MERCK & CO. INC. (US) | 2009-06-16 | — | — | US | disclosed |
| US-7528163-B2 | N,N-Dibutyl-2-[3-(2,2-dimethylpropanoyl)-6-methoxy-1H-indazol-1-yl]acetamide; potassium channel blocker; eye neuroprotectant; hypotensive agent; glaucoma, intraoccular pressure in the eye | MERCK & CO. INC. (US) | 2009-05-05 | — | — | US | disclosed |
| EP-1663987-B1 | OPHTHALMIC COMPOSITIONS FOR TREATING OCULAR HYPERTENSION | MERCK & CO INC (US) | 2009-03-18 | — | — | EP | disclosed |
| US-7410992-B2 | Ophthalmic compositions for treating ocular hypertension | MERCK & CO. INC. (US) | 2008-08-12 | — | — | US | disclosed |
| EP-1581503-A4 | OPHTHALMIC COMPOSITIONS FOR TREATING OCULAR HYPERTENSION | MERCK & CO INC (US) | 2007-07-25 | — | — | EP | disclosed |
| EP-1562909-A1 | OPHTHALMIC COMPOSITIONS FOR TREATING OCULAR HYPERTENSION | Merck & Co., Inc. (US) | 2005-08-17 | — | — | EP | disclosed |
| EP-1448758-B1 | IMPROVEMENTS RELATING TO DETERGENT BARS | UNILEVER NV (NL) | 2005-04-20 | — | — | EP | disclosed |
| WO-2005026128-A1 | OPHTHALMIC COMPOSITIONS FOR TREATING OCULAR HYPERTENSION | MERCK & CO., INC. (US) | 2005-03-24 | — | — | WO | disclosed |
| US-20050014666-A1 | Detergent bars | UNILEVER HOME & PERSONAL CARE USA, DIVISION OF CONOPCO, INC. | 2005-01-20 | — | — | US | disclosed |
| EP-1448758-A1 | IMPROVEMENTS RELATING TO DETERGENT BARS | UNILEVER N.V. (NL) | 2004-08-25 | — | — | EP | disclosed |
| WO-2004043933-A1 | OPHTHALMIC COMPOSITIONS FOR TREATING OCULAR HYPERTENSION | MERCK & CO., INC. (US) | 2004-05-27 | — | — | WO | disclosed |
| WO-2004043932-A1 | OPHTHALMIC COMPOSITIONS FOR TREATING OCULAR HYPERTENSION | MERCK & CO., INC. (US) | 2004-05-27 | — | — | WO | disclosed |
| WO-2004043354-A2 | OPHTHALMIC COMPOSITIONS FOR TREATING OCULAR HYPERTENSION | MERCK & CO., INC. (US) | 2004-05-27 | — | — | WO | disclosed |
| US-20040097575-A1 | Ophthalmic compositions for treating ocular hypertension | MERCK SHARP & DOHME LLC | 2004-05-20 | — | — | US | disclosed |
| WO-2003046119-A1 | IMPROVEMENTS RELATING TO DETERGENT BARS | UNILEVER N.V. (NL) | 2003-06-05 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040097575-A1 | Ophthalmic compositions for treating ocular hypertension | KCNH2, KCNJ11, KCNN1 | CA2 93/4885MAPK1 410/4885CA1 1477/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.