Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Naratriptan. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1D known ✓ | P28221 | 17/20 | 0.52 |
| ▸ | HTR1B known ✓ | P28222 | 17/20 | 0.52 |
| ▸ | HTR1A | P08908 | 8/20 | 0.52 |
| ▸ | HTR2A | P28223 | 6/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.52 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.52 |
| ▸ | HTR2B | P41595 | 3/20 | 0.49 |
| ▸ | HTR2C | P28335 | 2/20 | 0.49 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.49 |
| ▸ | HRH1 | P35367 | 1/20 | 0.49 |
| ▸ | HTR1F | P30939 | 2/20 | 0.46 |
| ▸ | HTR5A | P47898 | 2/20 | 0.46 |
| ▸ | HTR1E | P28566 | 1/20 | 0.46 |
| ▸ | HTR7 | P34969 | 1/20 | 0.46 |
| ▸ | HTR3A | P46098 | 1/20 | 0.46 |
| ▸ | SLC47A1 | Q96FL8 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Naratriptan SCHEMBL6235276 | 0.90 | HTR1D (0.64) | HTR1DHTR1BHTR1AHTR2AKMT2A | |
| Naratriptan SCHEMBL4946618 | 0.89 | HTR1D (0.65) | HTR1DHTR1BHTR1AHTR2AHTR2B | |
| Naratriptan SCHEMBL7865288 | 0.83 | HTR1D (0.76) | HTR1DHTR1BHTR1AHTR2AKMT2A | |
| Zolmitriptan SCHEMBL1585070 | 0.83 | HTR1D (0.76) | HTR1DHTR1BHTR1AHTR2AKMT2A | |
| Zolmitriptan SCHEMBL2484184 | 0.80 | HTR1D (0.82) | HTR1DHTR1BHTR1AHTR2AKMT2A | |
| Rizatriptan SCHEMBL1584683 | 0.79 | HTR1A (0.79) | HTR1DHTR1BHTR1AHTR2AHTR2B | |
| Zolmitriptan SCHEMBL6272592 | 0.77 | HTR1D (0.65) | HTR1DHTR1BHTR1AHTR2AKMT2A | |
| SCHEMBL7804355 | 0.74 | HTR1D (0.70) | HTR1DHTR1BHTR1AHTR2AKMT2A | |
| SCHEMBL9672029 | 0.74 | HTR1D (0.70) | HTR1DHTR1BHTR1AHTR2AKMT2A | |
| Naratriptan SCHEMBL8716118 | 0.73 | HTR1D (0.70) | HTR1DHTR1BHTR1AHTR2AHTR2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2081893-A2 | SUBSTITUTED INDOLES | Auspex Pharmaceuticals, Inc. (US) | 2009-07-29 | — | — | EP | disclosed |
| WO-2008049116-A2 | SUBSTITUTED INDOLES | AUSPEX PHARMACEUTICALS, INC. (US) | 2008-04-24 | — | — | WO | disclosed |