Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BTK | Q06187 | 18/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | HPGD | P15428 | 2/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | CD69 | Q07108 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3956979 | 0.99 | BTK (0.47) | BTKALDH1A1HPGDSMN1; SMN2MEN1 | |
| SCHEMBL3964067 | 0.91 | BTK (0.44) | BTKALDH1A1HPGDSMN1; SMN2MEN1 | |
| SCHEMBL3964057 | 0.88 | TDP1 (0.47) | BTKALDH1A1HPGDSMN1; SMN2MEN1 | |
| SCHEMBL3968149 | 0.82 | BTK (0.53) | BTKSMN1; SMN2MEN1POLBRAB9A | |
| SCHEMBL13893940 | 0.79 | BTK (0.53) | BTKALDH1A1HPGDSMN1; SMN2MEN1 | |
| SCHEMBL1322787 | 0.75 | BTK (0.76) | BTKCD69 | |
| SCHEMBL1321960 | 0.74 | BTK (0.58) | BTKALDH1A1RAB9AKDM4E | |
| SCHEMBL1321911 | 0.74 | BTK (0.77) | BTKCD69 | |
| SCHEMBL3965260 | 0.72 | BTK (0.46) | BTK | |
| SCHEMBL1321976 | 0.72 | BTK (0.57) | BTKCD69 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2081923-A1 | CERTAIN SUBSTITUTED AMIDES, METHOD OF MAKING, AND METHOD OF USE THEREOF | CGI Pharmaceuticals, Inc. (US) | 2009-07-29 | — | — | EP | disclosed |
| WO-2008033854-A1 | CERTAIN SUBSTITUTED AMIDES, METHOD OF MAKING, AND METHOD OF USE THEREOF | CGI PHARMACEUTICALS, INC. (US) | 2008-03-20 | — | — | WO | disclosed |