Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BTK | Q06187 | 16/20 | 0.53 |
| ▸ | BMX | P51813 | 1/20 | 0.45 |
| ▸ | KIT | P10721 | 1/20 | 0.44 |
| ▸ | SRC | P12931 | 1/20 | 0.44 |
| ▸ | FLT3 | P36888 | 1/20 | 0.44 |
| ▸ | ITK | Q08881 | 1/20 | 0.44 |
| ▸ | PPARG | P37231 | 2/20 | 0.44 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3956979 | 0.83 | BTK (0.47) | BTKKDM4EMEN1POLBRAB9A | |
| SCHEMBL3969273 | 0.82 | BTK (0.46) | BTKKDM4EMEN1POLBRAB9A | |
| SCHEMBL171471 | 0.78 | BTK (0.67) | BTKBMXKITSRCFLT3 | |
| SCHEMBL3953323 | 0.74 | BTK (0.51) | BTKBMXKITSRCFLT3 | |
| SCHEMBL13894298 | 0.74 | ITK (0.45) | BTKKITSRCFLT3ITK | |
| SCHEMBL3964067 | 0.74 | BTK (0.44) | BTKKDM4EMEN1POLBRAB9A | |
| SCHEMBL3870962 | 0.73 | BTK (0.70) | BTKBMXKITSRCFLT3 | |
| SCHEMBL3964057 | 0.72 | TDP1 (0.47) | BTKKDM4EMEN1POLBRAB9A | |
| SCHEMBL171935 | 0.71 | BTK (0.59) | BTKBMXKITSRCFLT3 | |
| SCHEMBL1322874 | 0.70 | BTK (0.77) | BTK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2081923-A1 | CERTAIN SUBSTITUTED AMIDES, METHOD OF MAKING, AND METHOD OF USE THEREOF | CGI Pharmaceuticals, Inc. (US) | 2009-07-29 | — | — | EP | disclosed |
| WO-2008033854-A1 | CERTAIN SUBSTITUTED AMIDES, METHOD OF MAKING, AND METHOD OF USE THEREOF | CGI PHARMACEUTICALS, INC. (US) | 2008-03-20 | — | — | WO | disclosed |